Aureobasidium pullulans metabolism of prostaglandins of the A-type

Prostaglandins
E M LeoveyP Bissonette

Abstract

Aureobasidium pullulans, originally introduced as an inadvertent contaminant in solutions used for evaluating the stability of prostaglandins, proved to lead to the rapid disappearance of the cyclopentenone unit of PGA2 (as monitored by circular dichroic spectroscopy). The cyclopentenone unit is converted, in various metabolites, to a 9-keto, 9 alpha or 9 beta-hydroxy group lacking the ring unsaturation. The major EtoAc-soluble 9-hydroxy metabolite (Compound-I) was shown to be 9 alpha, 15 alpha-dihydroxy-2, 3, 4, 5-tetranor-13-trans-prostenoic acid. Similar tetranor 9-hydroxy metabolites with one additional degree of unsaturation, and with a 9 beta-hydroxy group, also occur but these have not been fully characterized. Only two of the wide range of 9-keto metabolites are fully characterized by mass spectral (MS) data: 9, 15-oxo-2, 3, 4, 5-tetranorprostanoic acid and 9, 15-oxo-2, 3, 4, 5-tetranor-13-trans-prostenoic acid. The water soluble metabolites have not been characterized further. The fully characterized metabolites together with MS data from mixtures of minor metabolites indicate that A. pullulans can perform the following transformation: beta-oxidation, dehydrogenation at C-15, reduction of the enone carbon-carbon double...Continue Reading

References

Jul 1, 1977·Prostaglandins·N H AndersenD H Picker
Feb 19, 1975·Journal of the American Chemical Society·C J SihS S Lee
Mar 1, 1971·Archives of Biochemistry and Biophysics·B J Catley, W J Whelan
Sep 25, 1973·Biochimica Et Biophysica Acta·W J Marsheck, M Miyano
Mar 7, 1973·Journal of the American Chemical Society·C N SihL F Lee
May 17, 1972·Journal of the American Chemical Society·C J SihM Casey
Oct 1, 1970·The Biochemical Journal·R L Jones
Mar 11, 1969·Journal of Chromatography·J M Iacono, T T Ishikawa
Jul 1, 1956·Journal of General Microbiology·E S WYNNE, C L GOTT
May 10, 1962·Mycopathologia et mycologia applicata·W B COOKE
Dec 30, 1963·Mycopathologia et mycologia applicata·W B COOKE, G MATSUURA

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