Aureochaeglobosins A-C, Three [4 + 2] Adducts of Chaetoglobosin and Aureonitol Derivatives from Chaetomium globosum

Organic Letters
Ming-Hua YangLing-Yi Kong

Abstract

Aureochaeglobosins A-C (1-3), three novel [4 + 2] cycloaddition heterodimers of chaetoglobosin and aureonitol derivatives, were obtained from the culture of endophytic fungus Chaetomium globosum, representing the first adduct examples of chaetoglobosins. Their structures were elucidated by extensive spectroscopic analyses, single-crystal X-ray diffraction, and a modified Mosher's method. Compounds 2 and 3 showed significant cytotoxicities against human MDA-MB-231 cancer cells with IC50 values of 7.6 and 10.8 μM, respectively.

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Citations

Sep 22, 2018·Angewandte Chemie·Julius R ReyesDirk Trauner
Oct 17, 2018·Rapid Communications in Mass Spectrometry : RCM·Jacob P WalshMark W Sumarah
Dec 14, 2019·Natural Product Research·Xishan HuangRuiyun Yang
May 16, 2020·Organic & Biomolecular Chemistry·Xiaogang PengHanli Ruan

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