Aurora-A activation, correlated with hypoxia-inducible factor-1α, promotes radiochemoresistance and predicts poor outcome for nasopharyngeal carcinoma.

Cancer Science
Xiang-Bo WanQuentin Liu

Abstract

Previously, we and others showed that hypoxia-inducible factor-1α (HIF-1α) and transcriptionally upregulated Aurora-A were required for disease progression in several tumors. Here, we address the clinicopathologic value of Aurora-A and HIF-1α in locally advanced nasopharyngeal carcinoma (NPC). Aurora-A and HIF-1α expression was semiquantitatively evaluated by immunohistochemistry staining in 144 cases from a randomized controlled trial. Of these patients, 69 received neoadjuvant chemotherapy plus concurrent chemoradiotherapy, and acted as the training set, and 75 cases treated with neoadjuvant chemotherapy plus radiotherapy were used as the testing set to validate the prognostic effect of Aurora-A and HIF-1α. We found that Aurora-A and HIF-1α were highly expressed in NPC, but were deficient in normal adjacent epithelia. In the testing set, Aurora-A overexpression predicted a shortened 5-year overall survival (59.1% vs 82.5%, P = 0.024), progression-free survival (44.8% vs 79.8%, P = 0.004), and distant metastasis-free survival (43.0% vs 17.3%, P = 0.016). Multivariate regression analysis confirmed that Aurora-A was indeed an independent prognostic factor for death, recurrence, and distant metastasis both in the testing set and ...Continue Reading

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Citations

Jul 6, 2014·Head & Neck·Claramae Shulyn ChiaN Gopalakrishna Iyer
Jan 31, 2014·Journal of Experimental & Clinical Cancer Research : CR·Xiaoyu WuXuequan Yao
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Jun 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie ChenXiang-Yuan Wu
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Jan 14, 2017·Acta Oto-laryngologica·Jing ZhangLiangfang Shen
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Aug 31, 2018·The Tohoku Journal of Experimental Medicine·Jun MiyaguchiShizunobu Igimi
Oct 24, 2019·Cancer Control : Journal of the Moffitt Cancer Center·Xinjuan FanJian Zheng

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