Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer

Cancer Biology & Therapy
Xu-Hui ZhangDavid S Schrump

Abstract

Analysis of biopsies from a recent clinical trial suggested that Depsipeptide FK228 (DP) inhibits Aurora kinase expression in lung cancer cells. The present study was undertaken to confirm and extend these observations. Aurora A and B mRNA levels in lung cancer cells were considerably higher than levels in normal pulmonary epithelia. DP, TSA and SAHA inhibited Aurora A, Aurora B and survivin expression with kinetics that were remarkably similar within individual cell lines, and appeared to coincide with p53 expression status. These effects were not observed following treatment with geldanamycins. Inhibition of Aurora B transcription coincided with decreased H3K9Ac and H3K4Me2 activation marks, and accumulation of H3K9Me3, as well as MBD1, MBD2 and MBD3 repression marks within the minimal Aurora B promoter. Knockdown of MBD1, -2 or -3 did not reproducibly abrogate inhibition of Aurora or survivin expression by DP or TSA. DP and TSA decreased expression and altered localization of Aurora kinases and survivin, resulting in mitotic catastrophe in lung cancer cells. Aurora A, and Aurora B levels in lung cancer cells and normal respiratory epithelia were assessed using quantitative RT-PCR techniques. These methods, as well as as West...Continue Reading

Citations

Jan 20, 2004·Biochimica Et Biophysica Acta·Yusuke NakadeTakashi Murate
Jun 14, 2005·Biochimica Et Biophysica Acta·Sybille G E MeyerHerbert de Groot
May 8, 2004·Molecular and Cellular Endocrinology·C L ChikA K Ho
Nov 25, 1997·Biochimica Et Biophysica Acta·C R McMaster, R M Bell
Nov 5, 2002·Biochemical and Biophysical Research Communications·Soheyla ShabahangJosef Pfeilschifter
May 16, 2000·Chemistry and Physics of Lipids·M Langner, K Kubica
Sep 23, 2000·Chemistry and Physics of Lipids·J P Slotte
Sep 23, 2000·Chemistry and Physics of Lipids·M Krönke
Sep 23, 2000·Chemistry and Physics of Lipids·T LevadeR Salvayre
Nov 8, 2001·European Journal of Pharmacology·C HornussK Racké
Sep 3, 1998·European Journal of Pharmacology·D Meyer zu HeringdorfK H Jakobs
Apr 28, 2001·Prostaglandins & Other Lipid Mediators·S M Mandala
Mar 1, 2000·Journal of Neuroimmunology·J X Qiu, D M Marcus
Apr 20, 2001·Neurochemistry International·B MontiA Contestabile
Dec 4, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F GalvanoM Renis
Apr 2, 1999·Early Human Development·R RuedaA Gil
Apr 3, 2003·Experimental Gerontology·Nataliya S KavokNataliya A Babenko
Aug 5, 2000·Free Radical Biology & Medicine·G LeonarduzziG Poli
Feb 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R DziakL Bobek
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Peter P Ruvolo
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Benedetta CinqueM Grazia Cifone
Jun 25, 2003·Protein Expression and Purification·Willem F NieuwenhuizenFriedrich Götz
Jun 5, 2003·Biochimica Et Biophysica Acta·Kentaro Hanada
Sep 3, 2013·The Lancet Oncology·Ranee MehraErica A Golemis
Jan 30, 2008·Lipids in Health and Disease·Nataliya A Babenko, Elena G Shakhova
Dec 14, 2011·Journal of Cancer Research and Clinical Oncology·Kleiton Silva BorgesLuiz Gonzaga Tone
May 12, 2009·International Journal of Cancer. Journal International Du Cancer·Ahlame SaidiSophie Javerzat
May 22, 2009·Journal of Cellular Biochemistry·P A Marks, W-S Xu
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Anat BiranYoel Kloog
Mar 3, 2010·Medicinal Research Reviews·Dhanasekaran KarthigeyanTapas K Kundu
Nov 29, 2015·Seminars in Oncology·Gerald S FalchookRazelle Kurzrock

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.