PMID: 26854435Feb 9, 2016Paper

Aurora A overexpression in breast cancer patients induces taxane resistance and results in worse prognosis

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
Yalcin CirakErdem Cubukcu

Abstract

The aim of this study was to determine the expression level of Aurora A in human breast cancer tissues and to test whether there is a relationship between its expression levels and clinicopathological parameters including response to taxanes, tumor grade, estrogen receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, and overall survival (OS). We retrospectively analyzed paraffin-embedded tissue sections from 49 metastatic breast cancer patients whose clinical outcomes had been tracked after taxane treatment. The expression status of Aurora A was defined by immunohistochemistry (IHC) using the anti-Aurora A antibody. Aurora A was overexpressed in 73% of the examined specimens. There was significant correlation between high Aurora A expression and decreased taxane sensitivity (p=0.02). There was no association between the clinicopathological parameters including histologic grade, ER positivity and triple negative molecular subtype and the level of Aurora A expression. However, HER2 positive tumors showed significantly higher Aurora A expression compared with HER2 negative tumors (p=0.02). Kaplan-Meier survival analysis failed to show a significant correlation between expression levels of Aurora A and OS a...Continue Reading

Related Concepts

Taxane
HER2delta16 protein, human
AURKA protein, human
Mammary Neoplasms, Human
Bridged Compounds
Retrospective Studies
ErbB-2 Receptor
Antibiotic Resistance, Neoplasm
Taxanes
Aurora Kinase A

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