Aurora kinase A in Barrett's carcinogenesis

Human Pathology
Massimo RuggeErmanno Ancona

Abstract

In Barrett's mucosa, both aneuploidy and TP53 mutations are consistently recognized as markers of an increased risk of Barrett's adenocarcinoma. Overexpression of the mitotic kinase encoding gene (AURKA) results in chromosome instability (assessed from the micronuclei count) and ultimately in aneuploidy. Eighty-seven esophageal biopsy samples representative of all the phenotypic lesions occurring in the multistep process of Barrett's carcinogenesis (gastric metaplasia in 25, intestinal metaplasia in 25, low-grade intraepithelial neoplasia in 16, high-grade intraepithelial neoplasia in 11, and Barrett's adenocarcinoma in 10) were obtained from long segments of Barrett's mucosa. Twenty-five additional biopsy samples of native esophageal mucosa were used for control purposes. In all tissue samples, the immunohistochemical expression of both AURKA and TP53 gene products was scored; and the micronuclei index was calculated. AURKA immunostaining increased progressively and significantly along with dedifferentiation of the histologic phenotype (P < .001). Nine of 10 Barrett's adenocarcinomas showed AURKA immunostaining. AURKA expression correlated significantly with p53 expression and the micronuclei index (both Ps < .001). AURKA over...Continue Reading

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Citations

Jan 6, 2012·World Journal of Gastroenterology : WJG·Matteo FassanMassimo Rugge
May 30, 2015·Expert Opinion on Emerging Drugs·Bruno VincenziGiuseppe Tonini
Aug 14, 2012·Histopathology·Matteo FassanMassimo Rugge
May 20, 2015·Molecular Cancer·Ahmed KatshaWael El-Rifai
Oct 2, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Elmas KasapMehmet Korkmaz
Apr 24, 2012·Human Pathology·Marco PizziMassimo Rugge
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Caryn S Ross-InnesUNKNOWN BEST2 study group
Dec 4, 2010·International Journal of Cancer. Journal International Du Cancer·Matteo FassanMassimo Rugge
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Nov 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vikas SehdevWael El-Rifai

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