Aurora kinase inhibitor VX‑680 suppresses the proliferation and migration of HUVECs and angiogenesis

Molecular Medicine Reports
Xue-Jiao SunXiaoxia Wang

Abstract

Angiogenesis serves a key role in tumor growth and metastasis. VX‑680, a potent inhibitor targeting the Aurora kinase family, is widely used in the inhibition of tumor progression. However, the effect of VX‑680 on angiogenesis remains unknown. The present study identified that VX‑680 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and promoted HUVEC apoptosis by inducing the cleavage of PARP and caspase‑3. VX‑680 also markedly decreased the migration and tube formation of HUVECs in a dose‑dependent manner. In addition, VX‑680 significantly suppressed the formation of blood vessels in a dose‑dependent manner confirmed by a chicken embryo chorioallantoic membrane assay in vivo. Furthermore, VX‑680 inhibited the expression levels of vascular endothelial growth factor and phosphorylated RAC‑α serine/threonine‑protein kinase in HUVECs. These results suggested that VX‑680 suppressed angiogenesis and may be a potential novel anti‑angiogenic agent.

References

Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Eugene S KimDarrell J Yamashiro
Aug 28, 2004·Expert Opinion on Investigational Drugs·Sheila A Doggrell
Feb 28, 2007·Critical Reviews in Oncology/hematology·Robert Roskoski
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yvonne G LinAnil K Sood
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Warren FiskusKapil Bhalla
Mar 24, 2009·Methods in Molecular Biology·M Lourdes Ponce
Dec 15, 2010·Current Medicinal Chemistry·G PortellaP Chieffi
Aug 31, 2011·Drug Discovery Today·Francesco BertoliniAlberto D'Onofrio
Jul 5, 2012·The Keio Journal of Medicine·Yoshiaki Kubota
Oct 21, 2016·Medicinal Research Reviews·Min YanQuentin Liu

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Citations

Feb 6, 2020·British Journal of Pharmacology·Li-Na ZhangJia-Jie Chen

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