Abstract
Angiogenesis serves a key role in tumor growth and metastasis. VX‑680, a potent inhibitor targeting the Aurora kinase family, is widely used in the inhibition of tumor progression. However, the effect of VX‑680 on angiogenesis remains unknown. The present study identified that VX‑680 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and promoted HUVEC apoptosis by inducing the cleavage of PARP and caspase‑3. VX‑680 also markedly decreased the migration and tube formation of HUVECs in a dose‑dependent manner. In addition, VX‑680 significantly suppressed the formation of blood vessels in a dose‑dependent manner confirmed by a chicken embryo chorioallantoic membrane assay in vivo. Furthermore, VX‑680 inhibited the expression levels of vascular endothelial growth factor and phosphorylated RAC‑α serine/threonine‑protein kinase in HUVECs. These results suggested that VX‑680 suppressed angiogenesis and may be a potential novel anti‑angiogenic agent.
References
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Eugene S KimDarrell J Yamashiro
Aug 28, 2004·Expert Opinion on Investigational Drugs·Sheila A Doggrell
Jan 24, 2007·Cancer Letters·G M T CheethamJ R Pollard
Feb 28, 2007·Critical Reviews in Oncology/hematology·Robert Roskoski
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yvonne G LinAnil K Sood
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Warren FiskusKapil Bhalla
Mar 24, 2009·Methods in Molecular Biology·M Lourdes Ponce
Dec 15, 2010·Current Medicinal Chemistry·G PortellaP Chieffi
May 24, 2011·Journal of Translational Medicine·Duo-Rong XuQuentin Liu
Aug 31, 2011·Drug Discovery Today·Francesco BertoliniAlberto D'Onofrio
Jul 5, 2012·The Keio Journal of Medicine·Yoshiaki Kubota
Jul 10, 2012·Leukemia·F J GilesJ E Cortes
Jul 31, 2013·Molecular Cancer·Sarita SaraswatiAbdulqader A Alhaider
Nov 23, 2013·Molecular Cancer·Sarita SaraswatiAbdulqader A Alhaider
Dec 19, 2013·Oncology Letters·Rucheng YaoRongchun Xing
Aug 16, 2014·Blood Cancer Journal·J F SeymourF J Giles
Apr 18, 2015·BMC Complementary and Alternative Medicine·Han-Jin CuiTao Tang
Nov 18, 2015·Oncotarget·Xiao Yu WuLiang Shen
Mar 12, 2016·Oncotarget·Min SuZhiyong Luo
Apr 16, 2016·Cancer Biology & Therapy·Xin JinPingbo Chen
May 15, 2016·Investigational New Drugs·Raffaele PezzaniMarco Boscaro
Oct 21, 2016·Medicinal Research Reviews·Min YanQuentin Liu
Aug 2, 2017·Chemico-biological Interactions·Sonia SharmaShashi Bhushan