Aurora kinase inhibitors--rising stars in cancer therapeutics?

Molecular Cancer Therapeutics
Altaf A DarWael El-Rifai

Abstract

Standard therapeutic approaches of cytotoxics and radiation in cancer are not only highly toxic, but also of limited efficacy in treatment of a significant number of cancer patients. The molecular analysis of the cancer genomes have shown a remarkable complexity and pointed to key genomic and epigenomic alterations in cancer. These discoveries are paving the way for targeted therapy approaches. However, although there are a large number of potential targets, only a few can regulate key cellular functions and intersect multiple signaling networks. The Aurora kinase family members (A, B, and C) are a collection of highly related and conserved serine-threonine kinases that fulfill these criteria, being key regulators of mitosis and multiple signaling pathways. Alterations in Aurora kinase signaling are associated with mitotic errors and have been closely linked to chromosomal aneuploidy in cancer cells. Several studies have shown amplification and/or overexpression of Aurora kinase A and B in hematologic malignancies and solid tumors. Over the past several years, Aurora kinases have become attractive targets. Several ongoing clinical trials and bench-based research are assessing the unique therapeutic potential of Aurora-based tar...Continue Reading

References

Oct 8, 1998·Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology·M AbadA Orfao
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·D C FarruggioJ V Ruderman
Jul 7, 1999·Journal of the National Cancer Institute·H KatayamaM Tatsuka
Sep 15, 1999·Nature·A Khwaja
Dec 14, 1999·The American Journal of Pathology·W L Lingle, J L Salisbury
Feb 13, 2001·Trends in Cell Biology·R R AdamsW C Earnshaw
Apr 18, 2003·Current Biology : CB·Patrick A EyersJames L Maller
Apr 30, 2003·The Journal of Cell Biology·Claire DitchfieldStephen S Taylor
Oct 3, 2003·The Journal of Biological Chemistry·Tomotoshi MarumotoHideyuki Saya
Mar 3, 2004·The Journal of Biological Chemistry·Mutsuko OuchiToru Ouchi
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yung-Ming JengHey-Chi Hsu
Apr 28, 2004·Current Opinion in Genetics & Development·Patrick MeraldiErich A Nigg
Oct 8, 2004·The Journal of Biological Chemistry·Qiyuan LiuJin Q Cheng
Mar 26, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Henryk BarthelEric O Aboagye
Jul 20, 2005·Oncogene·Akifumi KandaMasaaki Tatsuka
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chiara SonciniJürgen Moll
Aug 9, 2006·International Journal of Cancer. Journal International Du Cancer·Hua YangJin Q Cheng
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mark G ManfrediChristopher F Claiborne
Jun 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert W WilkinsonStephen Green
Aug 21, 2007·Biochemistry·Kelly AndersonZhihong Lai
Sep 21, 2007·The Journal of Biological Chemistry·Eric BourhisAndrea G Cochran

❮ Previous
Next ❯

Citations

Aug 7, 2012·Cellular and Molecular Life Sciences : CMLS·Anna S NikonovaErica A Golemis
Oct 8, 2013·Breast Cancer Research and Treatment·Giovanni CirielloNikolaus Schultz
Jul 31, 2012·Pathology Oncology Research : POR·Katalin Hegyi, Gábor Méhes
May 31, 2013·Paediatric Drugs·Rejin Kebudi, Fatma Betul Cakir
May 17, 2011·Nature Cell Biology·Elsa Kress, Monica Gotta
Aug 2, 2012·Biochemistry Research International·Geun-Hyoung Ha, Eun-Kyoung Yim Breuer
Sep 12, 2012·BMC Complementary and Alternative Medicine·Yi-Jen HsiehChih-Jui Chang
Sep 13, 2013·BMC Medical Genomics·Xiaosheng Wang, Richard Simon
Dec 12, 2012·Genome Biology·Guanming Wu, Lincoln Stein
Jun 8, 2011·PloS One·Mary Kate BonnerAhna R Skop
Oct 31, 2012·PloS One·Catherine E BondVicki L J Whitehall
Jul 3, 2010·Journal of Neurosurgery. Pediatrics·Valerie N BartonRajeev Vibhakar
Jul 2, 2014·Drug Discovery Today. Disease Mechanisms·Tamina Seeger-NukpezahErica A Golemis
Sep 7, 2014·Cancer Letters·Carolien BoeckxFilip Lardon
Feb 14, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ning ZhouDonna E Hansel
Jun 27, 2014·Expert Opinion on Therapeutic Patents·Chun Hei Antonio CheungMohane Selvaraj Coumar
Mar 6, 2012·Expert Opinion on Investigational Drugs·Anna Lena MerkelMatthias Ocker
Apr 17, 2013·Expert Opinion on Investigational Drugs·Michel D WissingHans Gelderblom
Mar 2, 2013·Expert Opinion on Emerging Drugs·Francesca CasaluceCesare Gridelli
May 30, 2015·Expert Opinion on Emerging Drugs·Bruno VincenziGiuseppe Tonini
Jan 21, 2014·Journal of Pediatric Surgery·Carmelle RomainDai H Chung
Mar 28, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fang XieLong Yu
Oct 27, 2015·Future Medicinal Chemistry·Nelly Fosu-MensahAndrew D Westwell
Sep 18, 2010·International Journal of Cancer. Journal International Du Cancer·Yi GongJin-Rong Zhou
Feb 13, 2013·American Journal of Medical Genetics. Part a·Scott R PlotkinMarco Giovannini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biochimica Et Biophysica Acta
Hiroshi Katayama, Subrata Sen
Biochimica Et Biophysica Acta
Gerben Vader, Susanne M A Lens
Nature Reviews. Cancer
Tomotoshi MarumotoHideyuki Saya
© 2021 Meta ULC. All rights reserved