PMID: 3159821Jul 1, 1985Paper

Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages

The Journal of Experimental Medicine
W A JefferiesA F Williams


The rat W3/25 antigen that appears to be equivalent to human CD4 (T4) antigen is expressed on thymocytes and T helper cells and plays a role in the response of T helper cells to antigen. The W3/25 and anti-T4 antibodies also label macrophages. In this paper we examine whether the macrophage antigen is the same as that on T cells. New monoclonal antibodies against the rat CD4 antigen, MRC OX-35 through OX-38, are described, all of which label peritoneal macrophages from normal and athymic rats. The molecular weight of W3/25 antigen on macrophages is indistinguishable from that on T cells. We conclude that macrophages express authentic CD4 (W3/25) antigen. Another new monoclonal antibody, MRC OX-34, labels an antigen of 50-54,000 mol wt that is expressed on rat T but not B cells or peritoneal macrophages. It was used to control for the presence of any T cell products in immunoprecipitation from rat macrophage extracts.


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Jan 1, 1983·Immunological Reviews·D W MasonM L Thomas
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T H WattsH M McConnell
Jul 1, 1981·Cell and Tissue Kinetics·S V Hunt, M H Fowler

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