PMID: 3159821Jul 1, 1985Paper

Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages

The Journal of Experimental Medicine
W A JefferiesA F Williams

Abstract

The rat W3/25 antigen that appears to be equivalent to human CD4 (T4) antigen is expressed on thymocytes and T helper cells and plays a role in the response of T helper cells to antigen. The W3/25 and anti-T4 antibodies also label macrophages. In this paper we examine whether the macrophage antigen is the same as that on T cells. New monoclonal antibodies against the rat CD4 antigen, MRC OX-35 through OX-38, are described, all of which label peritoneal macrophages from normal and athymic rats. The molecular weight of W3/25 antigen on macrophages is indistinguishable from that on T cells. We conclude that macrophages express authentic CD4 (W3/25) antigen. Another new monoclonal antibody, MRC OX-34, labels an antigen of 50-54,000 mol wt that is expressed on rat T but not B cells or peritoneal macrophages. It was used to control for the presence of any T cell products in immunoprecipitation from rat macrophage extracts.

References

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Citations

Feb 1, 1996·The Anatomical Record·E Van VugtR H Beelen
Dec 8, 1998·European Journal of Immunology·A Pelchen-MatthewsM Marsh
Apr 1, 1991·Annals of Neurology·M Poltorak, W J Freed
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Jan 1, 1989·Neuroscience·V H Perry, R D Lund
Jun 1, 1995·Neuroscience·A P ByrnesH M Charlton
May 1, 1997·Transplantation Proceedings·M N HylkemaP Nieuwenhuis
Aug 3, 1999·Journal of Neuroimmunology·K Kohyama, Y Matsumoto
May 2, 2002·Clinical and Experimental Immunology·M A ThielK A Williams
Sep 29, 2001·Kidney International·K E De GreefM E De Broe

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