Autism and Epilepsy: Exploring the Relationship Using Experimental Models

Epilepsy Currents
Carl E Stafstrom, Tim A Benke

Abstract

The common co-occurrence of autism and epilepsy suggests that certain neurobiological mechanisms are shared between these disorders. In particular, the profusion of novel genetic mutations being discovered in autism and epilepsy points to abnormalities in synapse formation and function that alter the balance between neuronal excitation and inhibition. Animal models can be informative in sorting out the medical and behavioral complexities in autism and epilepsy and the relationship between them. As mechanistic information accrues, it is anticipated that mutation- and pathway-specific targeted treatments can be developed.

References

May 1, 1995·Brain & Development·P G RossiP Visconti
May 23, 2002·Brain : a Journal of Neurology·Patrick F BoltonAndrew Pickles
Jul 30, 2002·Progress in Brain Research·Carl E Stafstrom
Aug 26, 2006·European Child & Adolescent Psychiatry·Roberto Canitano
Sep 27, 2006·Nature Neuroscience·Francesca HappéRobert Plomin
Sep 27, 2006·Nature Neuroscience·Matthew K Belmonte, Thomas Bourgeron
Dec 27, 2007·PloS One·Markus Wöhr, Rainer K W Schwarting
Nov 14, 2008·Brain & Development·Roberto TuchmanIsabelle Rapin
Apr 17, 2009·Autism : the International Journal of Research and Practice·Martin KnappJennifer Beecham
Jul 7, 2009·Nature Reviews. Neurology·Sanjay N Rakhade, Frances E Jensen
Sep 18, 2009·Pharmacology, Biochemistry, and Behavior·Markus Wöhr, Rainer K W Schwarting
Mar 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cynthia M SchumannEric Courchesne
Sep 28, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Katherine S Wallace, Sally J Rogers
Dec 15, 2010·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Jarred Garfinkle, Michael I Shevell
Jul 29, 2011·Pediatric Research·Hannah C GlassDonna M Ferriero
Dec 14, 2011·Journal of Developmental and Behavioral Pediatrics : JDBP·Georgina PeacockScott D Grosse
Feb 22, 2012·Developmental Medicine and Child Neurology·Sue WoolfendenKatrina Williams
Mar 3, 2012·Epilepsy & Behavior : E&B·Anne T Berg, Sigita Plioplys
Mar 30, 2012·Frontiers in Psychiatry·Yuri BozziMatteo Caleo
Apr 10, 2012·Annual Review of Neuroscience·Asha L BhakarMark F Bear
May 5, 2012·Journal of Autism and Developmental Disorders·Jing-Qiong Kang, Gregory Barnes
Sep 4, 2012·Handbook of Clinical Neurology·Gregory L HolmesOlivier Dulac
Oct 3, 2012·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Nicholas S Abend, Courtney J Wusthoff
Jan 18, 2013·Nature·Daniel H Ebert, Michael E Greenberg
Feb 12, 2013·Neurotoxicology and Teratology·Florence I RoulletJane A Foster
Apr 25, 2013·JAMA : the Journal of the American Medical Association·Jakob ChristensenMogens Vestergaard
Apr 30, 2013·Handbook of Clinical Neurology·Claude G WasterlainAmy S Wasterlain
Jun 12, 2013·PloS One·David N RuskinSusan A Masino
Jul 24, 2013·Annual Review of Genomics and Human Genetics·Guillaume HuguetThomas Bourgeron
Dec 10, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adam Michael StewartAllan V Kalueff
Jan 29, 2014·Nature Reviews. Neurology·Shafali S Jeste, Daniel H Geschwind
Feb 13, 2014·Pediatric Neurology·Elizabeth Berry-Kravis
Mar 8, 2014·Frontiers in Cellular Neuroscience·Swati BanerjeeManzoor A Bhat
Apr 2, 2014·Experimental Neurology·Joaquin N LugoAnne E Anderson
May 6, 2014·Frontiers in Molecular Neuroscience·Joaquin N LugoObi Okonkwo
Jun 10, 2014·JAMA Pediatrics·Ariane V S BuescherDavid S Mandell
Aug 16, 2014·Lancet Neurology·Michele SimonatoJacqueline A French

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Citations

Oct 12, 2016·Computational Intelligence and Neuroscience·L L Neves, L H A Monteiro
Dec 12, 2017·Current Opinion in Psychiatry·Jay Salpekar
Sep 1, 2015·Epilepsy Currents·Samuel F Berkovic
Oct 7, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Galen MissigWilliam A Carlezon
Nov 6, 2015·MMWR. Morbidity and Mortality Weekly Report·Wanjun CuiMarshalyn Yeargin-Allsopp
Apr 30, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Roberto KellerMaurizio Elia
Jun 29, 2018·Molecular Autism·Matthew BengerNicholas D Mazarakis

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