PMID: 11932990Apr 5, 2002Paper

Autism and the X chromosome: no linkage to microsatellite loci detected using the affected sibling pair method

American Journal of Medical Genetics
Chris K SchutzJ J A Holden

Abstract

The etiology of autism spectrum disorders (ASDs) is poorly understood, although it is clear that genetic factors play a major role. ASDs appear to be a heterogeneous group of disorders, making genetic analysis difficult in the absence of etiologically definable subgroups. The excess of males in the affected population has led to suggestions that an X-linked locus could play a role in the causation of autism or a related pervasive developmental disorder. To examine this, we have investigated the genotypes of 31 families with two or more affected boys, at a series of 16 highly polymorphic loci distributed along the X chromosome with an average interlocus distance of 12 cM, in order to identify regions of significantly increased concordance among pairs of affected brothers. No locus tested showed a significant increase in concordance, supporting findings by others that there are no genes of major effect located on the X chromosome that contribute to increased susceptibility to ASD.

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Citations

Feb 14, 2003·Current Neurology and Neuroscience Reports·Maria T Acosta, Phillip L Pearl
Jun 23, 2011·PLoS Biology·Simon Baron-CohenRebecca Knickmeyer
Apr 9, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Susan L Santangelo, Katherine Tsatsanis
May 19, 2005·Psychiatric Genetics·John B VincentHugh M D Gurling

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