Jul 7, 2016

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products.

BioRxiv : the Preprint Server for Biology
Chris J Carter, R A Blizard

Abstract

The increasing incidence of autism suggests a major environmental influence. Epidemiology has implicated many candidates and genetics many susceptibility genes. Gene/environment interactions in autism were analysed using 206 autism genes (ASGs) to interrogate ~1 million chemical/gene interactions in the comparative toxicogenomics database. Bias towards ASGs was statistically determined for each chemical. Many suspect compounds identified in epidemiology, including tetrachlorodibenzodioxin, pesticides, particulate matter, benzo(a)pyrene , heavy metals, valproate, acetaminophen, SSRIs, cocaine, bisphenol A, phthalates, polyhalogenated biphenyls, flame retardants, diesel constituents , terbutaline and oxytocin, inter alia showed a significant degree of bias towards ASGs, as did relevant endogenous agents (retinoids, sex steroids, thyroxine, melatonin, folate, dopamine, serotonin). Numerous other endocrine disruptors selectively targeted ASGs including paraquat, atrazine and other pesticides not yet studied in autism and many compounds used in food, cosmetics or household products, including tretinoin, soy phytoestrogens , aspartame, titanium dioxide and sodium fluoride. Autism polymorphisms are known to influence sensitivity to so...Continue Reading

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Mentioned in this Paper

Hydrocarbons, Polyhalogenated
Sodium Fluoride
Gene Polymorphism
Acetaminophen
Endocrine Disruptors
Atrazine
Valproate
Aspartame
Genes
Trees (plant)

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