Autism Spectrum Disorders and Other Mental Health Problems: Exploring Etiological Overlaps and Phenotypic Causal Associations

Journal of the American Academy of Child and Adolescent Psychiatry
Beata TickFruhling Rijsdijk

Abstract

Recent studies have highlighted the impact of coexisting mental health problems in autism spectrum disorders (ASD). No twin studies to date have reported on individuals meeting diagnostic criteria of ASD. This twin study reports on the etiological overlap between the diagnosis of ASD and emotional symptoms, hyperactivity, and conduct problems measured with the Strengths and Difficulties Questionnaire. Genetic and environmental influences on the covariance between ASD and coexisting problems were estimated, in line with the correlated risks model prediction. Phenotypic causality models were also fitted to explore alternative explanations of comorbidity: namely, that coexisting problems are the result of or result in ASD symptoms; that they increase recognition of ASD; or that they arise due to an over-observation bias/confusion when differentiating between phenotypes. More than 50% of twins with broad spectrum/ASD met the borderline/abnormal levels cut-off criteria for emotional symptoms or hyperactivity, and approximately 25% met these criteria for the 3 reported problems. In comparison, between 13% and 16% of unaffected twins scored above the cut-offs. The phenotypic correlation between ASD and emotional symptoms was explained...Continue Reading

References

May 1, 1987·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S J Holmes, L N Robins
Jul 1, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·R Goodman
Aug 18, 2000·Journal of Child Psychology and Psychiatry, and Allied Disciplines·R GoodmanH Meltzer
Aug 18, 2000·Journal of Child Psychology and Psychiatry, and Allied Disciplines·E Simonoff
Mar 29, 2002·Autism : the International Journal of Research and Practice·Fiona J ScottCarol Brayne
Jul 26, 2002·Briefings in Bioinformatics·Frühling V Rijsdijk, Pak C Sham
May 5, 2004·Archives of General Psychiatry·Jane ScourfieldPeter McGuffin
Dec 25, 2004·Autism : the International Journal of Research and Practice·Jo WilliamsCarol Brayne
Sep 17, 2005·Psychological Medicine·F V RijsdijkP C Sham
Jul 18, 2006·Journal of Autism and Developmental Disorders·Ovsanna T LeyferJanet E Lainhart
Jan 29, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Angelica RonaldRobert Plomin
Jul 23, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Emily SimonoffGillian Baird
Apr 18, 2009·Journal of Autism and Developmental Disorders·Katharina DworzynskiAngelica Ronald
Feb 12, 2010·European Child & Adolescent Psychiatry·Nanda N J RommelseJan K Buitelaar
May 19, 2010·The American Journal of Psychiatry·Victoria HallettFrancesca Happé
May 4, 2011·Archives of General Psychiatry·Traolach S BrughaHoward Meltzer
Aug 30, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Beate St PourcainDavid H Skuse
Dec 14, 2011·Journal of Abnormal Child Psychology·Victoria HallettFrancesca Happé
Jul 31, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Katharina DworzynskiFrancesca Happé
Sep 1, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Emily SimonoffTony Charman
Sep 26, 2012·Journal of Autism and Developmental Disorders·Cara E PuglieseThomas H Ollendick
Nov 1, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Claire M A HaworthRobert Plomin
Apr 1, 2011·Psychometrika·Steven BokerJohn Fox
May 17, 2013·Molecular Autism·Rebecca GrzadzinskiCatherine Lord
Aug 27, 2013·Journal of Abnormal Child Psychology·Aline ScherffAngelica Ronald
Sep 3, 2013·The Journal of Nervous and Mental Disease·Michael B First
Jan 21, 2015·European Child & Adolescent Psychiatry·Mark J TaylorAngelica Ronald
Mar 5, 2015·JAMA Psychiatry·Emma ColvertPatrick Bolton

❮ Previous
Next ❯

Citations

Nov 3, 2016·Current Opinion in Pediatrics·Francesca Happé, Jane R Conway
Jul 3, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Elizabeth ShephardUNKNOWN BASIS Team
Aug 7, 2020·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Gavin R StewartFrancesca Happé
Apr 21, 2017·Annual Review of Genomics and Human Genetics·Pauline ChasteBernie Devlin
Nov 30, 2016·Autism Research : Official Journal of the International Society for Autism Research·Elizabeth ShephardUNKNOWN BASIS Team
Sep 14, 2017·Journal of Autism and Developmental Disorders·Elizabeth ShephardGrainne McLoughlin
Jan 30, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Francesca Happé, Uta Frith
Oct 11, 2020·Journal of Autism and Developmental Disorders·Mutluhan ErsoyUNKNOWN BASIS Team
Jan 22, 2021·Journal of Autism and Developmental Disorders·Patricia Howlin
Sep 10, 2020·Cold Spring Harbor Perspectives in Medicine·Tom A McAdamsJean-Baptiste Pingault
Aug 11, 2021·Journal of Autism and Developmental Disorders·Chiara BaianoUNKNOWN LabNPEE Group
Aug 19, 2021·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Arianna ManziniIlina Singh
Aug 21, 2021·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Laura GhirardiMark J Taylor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Autism: Treatment Targets

The absence of effective treatments for autism are due to the high clinical and genetic heterogeneity between affected individuals, restricted knowledge of the underlying pathophysiological mechanisms, and the lack of reliable diagnostic biomarkers. Identification of more homogenous biological subgroups is therefore essential for the development of novel treatments based on the molecular mechanisms underpinning autism and autism spectrum disorders. Find the latest research on autism treatment targets here.

Related Papers

Journal of Child Psychology and Psychiatry, and Allied Disciplines
Angelica RonaldRobert Plomin
Autism Research : Official Journal of the International Society for Autism Research
Georgina WarnerPatricia Howlin
© 2021 Meta ULC. All rights reserved