PMID: 9185129May 1, 1997Paper

Autistic disorder and the endogenous opioid system

Medical Hypotheses
L Sher

Abstract

The elevated activity of brain opioids has been implicated in the pathogenesis of autistic disorder. Research on plasma and cerebrospinal fluid levels of endogenous opioids in subjects with autistic disorder has produced conflicting results. The author suggests that the level of brain opioid activity is a contributing but not the determining factor in the pathogenesis of autistic disorder. The author further suggests that the development of autistic disorder is related to the interaction between the endogenous opioid system and various neurotransmitter systems in the brain.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R SpanagelT S Shippenberg
Jan 1, 1990·Brain & Development·C GillbergI Eriksson
Mar 1, 1987·Pediatric Neurology·D L RossR Hitzemann

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Citations

Dec 13, 2006·Behavior Genetics·Sylvie TordjmanPierre L Roubertoux
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Oct 26, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lv WangMichael J Sorich
Oct 31, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Laurence LalanneElisabeth Bacon
Jun 26, 2001·Medical Hypotheses·L Sher
Mar 3, 2012·Psychiatry Research·Barbara ČupićJelka Gabrilovac
Sep 3, 2010·Child and Adolescent Psychiatry and Mental Health·Marco ValentiGermana Sorge
Jul 23, 1999·Medical Hypotheses·L Sher
Sep 28, 1999·Medical Hypotheses·J R Brasić
Sep 11, 2012·Journal of Neurodevelopmental Disorders·Gregor KohlsRobert T Schultz
Aug 7, 2010·American Journal on Intellectual and Developmental Disabilities·Sigmund EldevikScott Cross
Feb 26, 2005·Science·Morton A GernsbacherMarian Sigman

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