Autistic-like behaviours and associated brain structural plasticity are modulated by oxytocin in maternally separated rats.

Behavioural Brain Research
Monireh MansouriMaryam Ardalan

Abstract

Early psycho-social experiences influence the developing brain and possible onset of various neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD). ASD is characterized by a variety of brain abnormalities, including alteration of oxytocin receptors in the brain. Recently, early life adverse experiences, such as maternal separation (MS), have been shown to constitute risk factors for ASD in preclinical studies. Therefore, the main aims of the current study were to i) explore the association between onset of autistic-like behaviours and molecular/structural changes in the brain following MS, and ii) evaluate the possible beneficial effects of oxytocin treatment on the same parameters. Male rats were exposed to the maternal separation from post-natal day (PND) 1 to PND14. After weaning, daily injections of oxytocin (1 mg/kg, ip) were administered (PND 22-30), followed by examination of autism-related behaviours at adolescence (PND 42-50). Brain structural plasticity was examined using stereological methods, and the plasma level of brain derived neurotrophic factor (BDNF) was analysed using ELISA. We found that maternal separation induced autistic-like behaviours, which was associated with increase in the hippocampal...Continue Reading

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Citations

Jan 29, 2021·International Journal of Molecular Sciences·Monireh MansouriMaryam Ardalan
May 4, 2021·Psychoneuroendocrinology·Fengmei WeiYuhong Jing

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