Autistic traits in epilepsy models: Why, when and how?

Epilepsy Research
Jana VelíškováPierre-Pascal Lenck-Santini

Abstract

Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models. We then discuss two of the potential pathological processes that could be shared between ASD and epilepsy. We first focus on functional implications of neuroinflammation including changes to excitable networks mediated by inflammatory regulators. Finally we examine mechanisms at the cellular and network level involved in neuronal excitability, timing and network coordination that may directly lead to behavioral disturbances present in both epilepsy and ASD. This mini-review summarizes the work first presented at an Investigators Workshop at the 2016 American Epilepsy Society meeting.

References

Oct 1, 1975·Physiology & Behavior·R S Dyer, D A Weldon
Apr 8, 2000·Neuroimmunomodulation·S HuC C Chao
Jul 11, 2000·Nature Genetics·J N FergusonJ T Winslow
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·A VezzaniT Bartfai
Jul 14, 2001·Journal of Autism and Developmental Disorders·K M BelsitoA W Zimmerman
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·Janusz SzyndlerAdam Plaznik
Mar 1, 2003·Molecular Psychiatry·L A WeissM H Meisler
Jul 10, 2003·Lancet Neurology·Roberto Tuchman, Isabelle Rapin
Nov 11, 2003·Genes, Brain, and Behavior·J L R Rubenstein, M M Merzenich
Nov 17, 2004·Annals of Neurology·Diana L VargasCarlos A Pardo
Mar 5, 2005·The Journal of Neuropsychiatry and Clinical Neurosciences·Jessica A HellingsStephen R Schroeder
Aug 24, 2005·Nature Medicine·Guo-Feng TianMaiken Nedergaard
Nov 24, 2005·Epilepsia·Annamaria Vezzani, Tiziana Granata
Mar 17, 2006·Epilepsy & Behavior : E&B·Gregory L Holmes, Pierre-Pascal Lenck-Santini
May 6, 2006·Neuron·Chang-Hyuk KwonLuis F Parada
Sep 8, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Manuel F Casanova
Sep 15, 2006·Behavioural Brain Research·Sheryl S MoyJacqueline N Crawley
Sep 26, 2006·Behavioural Brain Research·Mark H LewisJames W Bodfish
Dec 21, 2006·Nature Reviews. Neuroscience·Marlene BartosPeter Jonas
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ikuo OgiwaraKazuhiro Yamakawa
Nov 17, 2007·Behavioural Brain Research·M L ScattoniJ N Crawley
Mar 22, 2008·Endocrinology·Heon-Jin LeeW Scott Young
Jun 3, 2008·Behavioral Neuroscience·Corinne M SpencerRichard Paylor
Jul 29, 2008·Progress in Brain Research·Heon-Jin LeeW Scott Young
Sep 2, 2008·Clinical Genetics·A OrricoV Sorrentino
Sep 6, 2008·Neuroscience and Biobehavioral Reviews·Maria Luisa ScattoniLaura Ricceri
Jan 23, 2009·Journal of Neuroimmunology·Xiaohong LiMazhar Malik
May 21, 2009·Pediatric Research·Sarah J Spence, Mark T Schneider
Oct 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mark R EthertonThomas C Südhof
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jacqueline BlundellCraig M Powell
Feb 18, 2010·Future Neurology·Michael SeidenbergBruce Hermann
Mar 13, 2010·Annals of Neurology·Jonathan K KleenPierre Pascal Lenck-Santini
Mar 23, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Enzo EmanuelePierluigi Politi

❮ Previous
Next ❯

Citations

Oct 13, 2019·The European Journal of Neuroscience·Laëtitia Chauvière
Dec 14, 2018·Global Pediatric Health·Carlos A Salgado, Daniel Castellanos
Oct 29, 2020·Molecular Autism·Caroline KasseeGillian Einstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.