Autistic traits in psychotic disorders: prevalence, familial risk, and impact on social functioning.

Psychological Medicine
Tim B ZiermansGenetic Risk and Outcome of Psychosis (GROUP) Investigators

Abstract

Prevalence estimates of autistic traits in individuals with psychotic disorders (PD) vary greatly and it is unclear whether individuals with a familial risk (FR) for psychosis have an increased propensity to display autistic traits. Furthermore, it is unknown whether the presence of comorbid autism traits disproportionally affects the cognitive and behavioral aspects of social functioning in PD. In total, 504 individuals with PD, 587 unaffected siblings with FR, and 337 typical comparison (TC) individuals (16-50 years) were included. Autistic and psychotic traits were measured with the Autism Spectrum Quotient (AQ) and the Community Assessment of Psychic Experiences (CAPE). Social cognition was assessed with the Picture Sequencing Task (PST) and social behavior with the Social Functioning Scale (SFS). For PD 6.5% scored above AQ clinical cut-off (⩾32), 1.0% for FR, and 1.2% for TC. After accounting for age, sex, and IQ, the PD group showed significantly more autistic traits and alterations in social behavior and cognition, while FR and TC only displayed marginal differences. Within the PD group autistic traits were a robust predictor of social behavior and there were no interactions with positive psychotic symptoms. Levels of a...Continue Reading

References

Jun 1, 1990·Archives of General Psychiatry·J K WingN Sartorius
Jul 8, 1999·Cognition·R Langdon, M Coltheart
Mar 23, 2001·Journal of Abnormal Psychology·G A Miller, J P Chapman
Mar 3, 2005·The American Journal of Psychiatry·Nancy C AndreasenDaniel R Weinberger
Jul 12, 2005·Schizophrenia Bulletin·Ashok Malla, Jennifer Payne
Aug 27, 2005·Journal of Autism and Developmental Disorders·M R Woodbury-SmithS Baron-Cohen
Feb 28, 2008·Journal of Autism and Developmental Disorders·Rosa A HoekstraDorret I Boomsma
Jun 17, 2008·Schizophrenia Research·Michelle L EsterbergElaine F Walker
Jun 27, 2008·The Behavioral and Brain Sciences·Bernard Crespi, Christopher Badcock
Sep 3, 2010·Journal of Intellectual & Developmental Disability·Fiona E PadgettPaul A Tiffin
Oct 12, 2010·Schizophrenia Research·Petra S BarneveldHanna Swaab
Apr 13, 2011·Journal of Neurodevelopmental Disorders·Noah J SassonAysenil Belger
Jul 4, 2012·Archives of General Psychiatry·Patrick F SullivanPaul Lichtenstein
Mar 12, 2013·Early Intervention in Psychiatry·Conor DavidsonStephen Wright
Apr 9, 2013·European Child & Adolescent Psychiatry·Selene S A A FagelHerman Van Engeland
Nov 13, 2014·Nordic Journal of Psychiatry·Tove LugnegårdChristopher Gillberg
May 10, 2015·Neuroscience and Biobehavioral Reviews·Katharine ChisholmStephen J Wood
May 15, 2015·BMC Psychiatry·Anne KästnerHannelore Ehrenreich
May 15, 2015·Proceedings. Biological Sciences·Ahmad M Abu-AkelIan A Apperly
May 18, 2016·Social Neuroscience·Ahmad M Abu-AkelPeter C Hansen
May 25, 2016·Schizophrenia Bulletin·Ahmad Abu-AkelCarmel Mevorach
Oct 28, 2016·Nature Neuroscience·Menachem FromerPamela Sklar
Feb 6, 2017·Psychiatry Research·Debbie L KincaidCiaran Mulholland
May 20, 2017·The Australian and New Zealand Journal of Psychiatry·Ahmad Abu-AkelChristos Pantelis

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Citations

Mar 3, 2021·Journal of Psychiatric Research·Margherita BechiRoberto Cavallaro
Mar 2, 2021·Frontiers in Psychiatry·Noah J SassonTim B Ziermans
May 25, 2021·Psychiatry Research·Daniel MamahDavid M Ndetei
Jul 28, 2021·Schizophrenia Bulletin·Adela-Maria IsvoranuUNKNOWN GROUP Investigators

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