Auto IgG anti-IgE and IgG x IgE immune complex presence and effects on ELISA-based quantitation of IgE in canine atopic dermatitis, demodectic acariasis and helminthiasis

Veterinary Immunology and Immunopathology
B HammerbergS L Vaden

Abstract

Atopic dermatitis is a common allergic disease manifestation in dogs; however, there is no correlation between clinical disease and detectable total serum IgE. Auto antibodies of the IgG subclass against IgE may affect the detection of serum IgE by immunoassay and may be important in the regulation of IgE production by B cells. ELISA were developed to detect serum antibodies specific for IgE using a newly available canine monoclonal IgE of known antigen specificity, generated from a canine x murine heterohybridoma. To test for correlation of auto IgG anti-IgE levels with manifestation of atopic dermatitis, the sera from 101 atopic dogs were compared with sera from non-atopic dogs of various breeds, foxhounds manifesting clinical signs of demodectic acariasis and helminth parasitized random bred dogs for quantities of IgG anti-IgE measured in units/ml compared to a high titer standard serum. To test for serum effects on quantitation of IgE, known amounts of canine monoclonal IgE were added to various sera and measured by capture ELISA with detecting monoclonal antibodies specific for heat labile or heat stabile epitopes. Unheated sera from dogs manifesting clinical atopic dermatitis and helminth parasitized dogs had levels of Ig...Continue Reading

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Citations

Jul 13, 2000·Veterinary Immunology and Immunopathology·S GoedertG C Mudde
May 6, 2003·Veterinary Immunology and Immunopathology·A P FosterE J Hall
Mar 18, 2003·Vaccine·Chang Yi WangDonald W MacGlashan
Oct 13, 2009·Veterinary Immunology and Immunopathology·Bruce Hammerberg
Dec 11, 2007·Veterinary Immunology and Immunopathology·Thierry OlivryBruce Hammerberg
Dec 15, 2010·Veterinary Dermatology·Thierry OlivryStanley M Dunston
May 12, 2004·Veterinary Immunology and Immunopathology·Melinda J WilkersonMichael Dryden
Jun 12, 2016·Veterinary Immunology and Immunopathology·Elizabeth A Layne, Douglas J DeBoer
Apr 8, 2003·World Journal of Gastroenterology : WJG·Chao-Pin LiYe Tian
Apr 28, 2004·World Journal of Gastroenterology : WJG·Rong-Bo ZhangYu-Bao Cui

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