Auto-immune (lupoid) hepatitis: an entity in the spectrum of chronic active liver disease

Journal of Gastroenterology and Hepatology
I R Mackay

Abstract

The concept of auto-immune hepatitis as a disease entity evolved from the descriptions of 'chronic active hepatitis' (CAH) in the 1950s. Several types of CAH are distinguished by disease-specific features. The distinctive (but not exclusive) markers for auto-immune CAH include: a negative test for HBsAg; female; Northern European ethnic background; multisystem disease expression; histological CAH with large areas of periportal piecemeal necrosis and plasmacytosis; pronounced hypergammaglobulinaemia; serum auto-antibodies the HLA B8-DR3 phenotype; responsiveness to corticosteroid therapy; and rarity of supervening hepatocellular carcinoma. Much weight is attached to the serological marker auto-antibodies to nuclear or smooth muscle (actin) antigens (ANA, SMA). However, these auto-antibodies do not have an absolute association with auto-immune CAH: the serological reactions are not yet standardized; titres decrease with remission of disease; and other auto-antibodies mark variant forms of auto-immune hepatitis. A more confident acceptance of auto-immune hepatitis as an entity requires detection of a liver-specific antigen, a valid experimental disease model in animals, and a better understanding of immune-mediated damage to liver...Continue Reading

References

Feb 1, 1979·European Journal of Clinical Investigation·E R Kuutti-SavolainenK I Kivirikko
Sep 20, 1979·Biochimica Et Biophysica Acta·D FekkesT J Visser
Jan 1, 1979·Clinical Immunology and Immunopathology·C M WeemaesP J van Munster
Oct 10, 1975·Brain Research·G L Gebber
Oct 1, 1975·The British Journal of Disorders of Communication·C L Davies, P Grunwell
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K K Wang, A J Czaja
Aug 5, 1989·Lancet·J I EstebanM Buti
Apr 1, 1989·Clinical Immunology and Immunopathology·F KonikoffY Shoenfeld
Oct 1, 1988·Clinical Immunology and Immunopathology·J Wesierska-GadekG Sauermann
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I H FrazerI R Mackay
Oct 14, 1972·Lancet·I R Mackay, P J Morris
Sep 14, 1968·Lancet·J De GrooteE Uehlinger
May 1, 1973·The American Journal of Digestive Diseases·R G Strickland, I R Mackay
Oct 1, 1972·Annals of Internal Medicine·I Mackay
Jan 1, 1972·International Archives of Allergy and Applied Immunology·J M Dwyer, I R Mackay
Dec 1, 1984·Clinical Science·I G McFarlane
Jul 1, 1956·The American Journal of Medicine·A G BEARNR J SLATER
Dec 29, 1956·Lancet·D C COWLINGL I TAFT

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Citations

Apr 5, 2013·PloS One·Chun-Chou TsaiTsai-Ching Hsu
Nov 24, 2004·The Veterinary Quarterly·P J J MandigersJ Rothuizen
Oct 19, 2016·Digestive Diseases and Sciences·Aldo J Montano-LozaAlbert J Czaja
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P J Johnson, I G McFarlane
May 1, 1991·Journal of Gastroenterology and Hepatology·I R Mackay
Mar 7, 2002·Journal of Psychiatric and Mental Health Nursing·C Forchuk, W Reynolds
Jan 1, 1996·FEMS Immunology and Medical Microbiology·M B KalvenesG Haukenes
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·G Gitnick
Jul 7, 1990·BMJ : British Medical Journal·J C BlakeA K Burroughs
Feb 1, 1991·Gastroenterologia Japonica·I R Mackay
Sep 3, 1990·The Medical Journal of Australia·I R Mackay

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