PMID: 3769971Aug 1, 1986Paper

Auto-immunity in children with diabetes mellitus and in their relatives

European Journal of Pediatrics
R LoriniF Severi

Abstract

Islet cell antibodies (ICA-IgG and complement-fixing-ICA), parietal cell antibodies (PCA), intestinal epithelial cell antibodies (IECA), thyroglobulin (TgA) and thyroid microsomal antibodies (MsA), antinuclear (ANA) and reticulin antibodies (RA), were studied in 55 insulin-dependent diabetic patients (30 males and 25 females), aged 2-19 years with diabetes from a few days up to 14 years. In 58% of the diabetics one or more autoantibodies were found: ICA-IgG (31%), CF-ICA (16%), PCA (34%), TgA (9%), MsA (9%), ANA (13%), RA (2%). Autoantibodies were significantly more frequent in females (76%) than in males (43%) (P less than 0.025). ICA-IgG, CF-ICA, PCA, ANA were significantly more frequent in patients than in controls. The frequency of ICA-IgG and CF-ICA was significantly higher during the first 3 years of disease than afterwards (P less than 0.001); a similar pattern was observed for PCA, TgA, MsA. Of the 87 parents and 30 siblings screened for ICA-IgG, CF-ICA, PCA, IECA, TgA, MsA, ANA and RA, 42 (44%) had one or more autoantibodies, which were more frequent in females than in males. Seven relatives (6%) were ICA-IgG positive (four mothers, two fathers and one brother), and only one mother, ICA-IgG negative, was CF-ICA positiv...Continue Reading

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Citations

Aug 1, 1989·European Journal of Pediatrics·R LoriniF Severi
Mar 1, 1992·European Journal of Pediatrics·L CortonaR Lorini
Nov 1, 1992·Human Immunology·M MartinettiG F Bottazzo
Jan 1, 1995·Journal of Diabetes and Its Complications·C CardosoS F KuKu
May 1, 1996·Journal of Diabetes and Its Complications·R LoriniF Severi
Jan 1, 1993·Diabetes Research and Clinical Practice·R LoriniF Severi
Jul 1, 1994·Diabetes Research and Clinical Practice·G d'AnnunzioR Lorini
Feb 1, 1994·Diabetes Research and Clinical Practice·R LoriniF Severi
Feb 1, 1994·Diabetes Research and Clinical Practice·G d'AnnunzioR Lorini
Jan 1, 1989·Autoimmunity·D LarizzaF Severi
Mar 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·R LoriniA Scaramuzza
Sep 27, 2005·Arquivos brasileiros de endocrinologia e metabologia·Otton Luis Raffo SouzaHenriqueta G G de Almeida
Jun 27, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·G d'AnnunzioR Lorini

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