Autoactivation of blood factor XII at hydrophilic and hydrophobic surfaces

Biomaterials
Rui ZhuoErwin A Vogler

Abstract

Contact activation of blood factor XII (FXII, Hageman factor) in neat-buffer solution is shown not to be specific for anionic hydrophilic procoagulants as proposed by the accepted biochemistry of surface activation. Rather, FXII activation in the presence of plasma proteins leads to an apparent specificity for hydrophilic surfaces that is actually due to a relative diminution of the FXII-->FXIIa reaction at hydrophobic surfaces. FXII activation in neat-buffer solution was effectively instantaneous upon contact with either hydrophilic (fully water-wettable clean glass) or hydrophobic (poorly water-wettable silanized glass) procoagulant particles, with greater FXIIa yield obtained by activation with hydrophobic procoagulants. In sharp contrast, both activation rate and yield was found to be significantly attenuated at hydrophobic surfaces in the presence of plasma proteins. Putative FXIIa produced by surface activation with both hydrophilic and hydrophobic procoagulants was shown to hydrolyze blood factor XI (FXI) to the activated form FXIa (FXIFXIIa-->FXIa) that causes FXI-deficient plasma to rapidly coagulate.

References

Jan 1, 1987·Annals of the New York Academy of Sciences·R W ColmanL H Edmunds
Nov 1, 1986·Journal of Biomedical Materials Research·A S Hoffman
Aug 1, 1995·Journal of Biomedical Materials Research·E A VoglerW J Brittain
Aug 1, 1995·Journal of Biomedical Materials Research·E A VoglerW J Brittain
Mar 1, 1994·Annals of Biomedical Engineering·K Gregory, D Basmadjian
Mar 25, 1998·Journal of Biomedical Materials Research·E A VoglerJ C Graper
Apr 30, 1998·Advances in Colloid and Interface Science·E A Vogler
Dec 11, 1999·Journal of Biomaterials Science. Polymer Edition·E A Vogler
Jan 17, 2002·The New England Journal of Medicine·E A RoseUNKNOWN Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group
Dec 19, 2002·Molecular & Cellular Proteomics : MCP·N Leigh Anderson, Norman G Anderson
Jul 14, 2005·Biomaterials·Rachel MillerChristopher A Siedlecki
Aug 16, 2005·Biomaterials·Zhe GuoChristopher A Siedlecki
May 17, 2006·Acta Biomaterialia·Rui ZhuoErwin A Vogler
Apr 29, 1966·Science·S N Levine

❮ Previous
Next ❯

Citations

Oct 24, 2009·Journal of Materials Science. Materials in Medicine·Marion FischerCarsten Werner
Feb 7, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·D X Beringer, L M J Kroon-Batenburg
Jul 25, 2013·Colloids and Surfaces. B, Biointerfaces·Alexandre F LeitãoMiguel Gama
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Li-Chong XuChristopher A Siedlecki
Oct 11, 2011·Biomaterials·Chyi-Huey Josh YehErwin A Vogler
Jun 21, 2011·Biomaterials·Erwin A Vogler
Jan 5, 2010·Acta Biomaterialia·Lars FaxälvTomas L Lindahl
Nov 7, 2009·Biomaterials·Avantika GolasErwin A Vogler
Jan 27, 2009·Biomaterials·Erwin A Vogler, Christopher A Siedlecki
May 17, 2008·Journal of Biomedical Materials Research. Part a·Kaushik ChatterjeeChristopher A Siedlecki
Oct 2, 2007·Journal of Biomedical Materials Research. Part a·Lars FaxälvTomas L Lindahl
Apr 13, 2011·Journal of Thrombosis and Haemostasis : JTH·E KilinçH M H Spronk
Jul 22, 2014·Journal of Biomedical Materials Research. Part a·Nuno AlexandreAna Lúcia Luís
Aug 15, 2006·Biomaterials·Kaushik ChatterjeeChristopher A Siedlecki
Jun 13, 2006·Biomaterials·Rui Zhuo, Erwin A Vogler
Apr 29, 2015·Colloids and Surfaces. B, Biointerfaces·Beata A Butruk-RaszejaMałgorzata Gonsior
Jul 19, 2015·Journal of Theoretical Biology·Vladislava A TerentyevaMikhail A Panteleev
Nov 18, 2011·Biomaterials·Erwin A Vogler
Aug 3, 2016·Biomaterials Science·Zihang PengChangsheng Zhao
Jul 24, 2007·Biomaterials·Rui ZhuoErwin A Vogler
Nov 5, 2016·Journal of Biomedical Materials Research. Part a·R Klopfleisch, F Jung
Jun 20, 2018·Macromolecular Bioscience·Guoying Zhou, Thomas Groth
Aug 4, 2018·Biomechanics and Modeling in Mechanobiology·John D HornJason M Ortega
May 4, 2013·Biological Chemistry·Jenny BjörkqvistThomas Renné
Dec 5, 2018·Npj Regenerative Medicine·A LongoniD Gawlitta
Dec 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xin LiNan Huang
Jul 2, 2020·Cardiovascular Engineering and Technology·Novella M BatesMonica T Hinds

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.