PMID: 591106Jan 1, 1977

Autoallergic states. Tumor immunology. Impaired function of peripheral lymphocytes in systemic lupus erythematosus

International Archives of Allergy and Applied Immunology
I Malavé, C Cuadra

Abstract

DNA synthesis by peripheral lymphocytes from active non-treated SLE patients and matched normal donors was assessed at various times after stimulation with high and low doses of PHA, PWM and ConA and in non-stimulated control cultures. The time response curve of SLE lymphocytes stimulated with a suboptimal dose of PHA, and with both optimal and suboptimal doses of PWM and ConA was markedly depressed, while their spontaneous DNA synthesis was significantly increased. Preincubation of the cells to remove putative coating antibodies did not revert the response of patients' lymphocytes to normal values. The antibody-induced cell-mediated lysis of 51Cr-labelled chicken results demonstrate that cellular factors contribute to the depressed in vitro responses in active SLE, suggesting a wide defect of lymphocyte populations in this disease.

Citations

Dec 1, 1979·CRC Critical Reviews in Clinical Laboratory Sciences·S B Taubman

Related Concepts

Antibody-Dependent Cellular Cytotoxicity
Autoimmune Diseases
DNA, Double-Stranded
Lupus Erythematosus, Systemic
Lymphocyte Activation
Lymphoid Cells
Animal Lectins

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