Autoantibodies against IA-2, GAD, and topoisomerase II in type 1 diabetic patients

Biochemical and Biophysical Research Communications
Yih-Hsin ChangMichael S Lan

Abstract

Prevalence of autoantibodies against IA-2 (IA-2A), glutamic acid decarboxylase (GADA), and type II DNA topoisomerase (TopIIA) of Taiwanese type 1 diabetes mellitus (T1DM) patients was investigated. Correlations of these autoantibodies with patients' clinical manifestations were also analyzed. Prevalence of IA-2A, GADA, and TopIIA in our patients was 23.6%, 47.1%, and 55.2%, respectively. Eighty percent of the IA-2A recognized the carboxyl terminus of the IA-2 protein tyrosine phosphatase-like domain. Average disease duration of IA-2A+ patients was significantly shorter than that of IA-2A- patients [3.76+/-0.42 vs. 4.98+/-0.34 years, p = 0.028]. Presence of GADA was correlated with the mean age of onset [10.82+/-0.76 vs. 8.38+/-0.77 years for GADA+ and GADA- patients, p = 0.026]. Patients with adolescent onset have higher GADA prevalence and better residual beta-cell functions. TopIIA and GADA are suggested to be better markers for Taiwanese T1DM patients because of their higher prevalence and persistence.

References

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Citations

Nov 26, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yi-Ching TungWen-Yu Tsai
Mar 25, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hiroki HiraiAbner L Notkins
Oct 24, 2013·Journal of Proteomics·Shane MierschJoshua LaBaer
Jul 15, 2021·Journal of Diabetes Research·Kun LinQiong Zeng
Oct 7, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Anna E LongClaire L Williams

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