Autoantibodies against muscarinic acetylcholine receptor M3 in Sjogren's syndrome and corresponding mouse models.

Frontiers in Bioscience (Landmark Edition)
Xinhua YuFrank Petersen

Abstract

Muscarinic acetylcholine receptor M3 (M3R) is a GPCR on exocrine gland cells involved in fluid secretion. In the last two decades, evidence has been accumulated arguing for a role of autoantibodies (aab) against M3R in the development of Sjögren's syndrome (SS). In this review, we provide an updated overview on this issue and critically discuss the relation between autoimmunity to M3R and SS pathogenesis. Clinical data as well as findings from experimental disease were summarized in categories addressing the presence of aab against M3R in SS patients, the function of anti-M3R aab, the association of aab against M3R with SS-related phenotypes, in vivo pathogenicity of transferred aab against M3R in mice, and mouse models induced via immunization with M3R. Based on these comprehensive data, we propose a hypothetic model for the role of aab against M3R in the pathogenesis of SS.

Citations

Jun 25, 2021·Frontiers in Medicine·Claudio VitaliNicoletta Del Papa
Sep 29, 2018·International Journal of Molecular Sciences·Marta TrzeciakUmesh S Deshmukh
Mar 7, 2019·Immune Network·Suk San ChoiJeehee Youn
Apr 3, 2021·Journal of Autoimmunity·Gilad HalpertYehuda Shoenfeld
Feb 23, 2020·International Journal of Molecular Sciences·Michie ImamuraShunya Nakane
Dec 5, 2020·International Journal of Molecular Sciences·Amrita Srivastava, Helen P Makarenkova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.