Autoantibodies as Potential Biomarkers in Breast Cancer

Biosensors
Jingyi QiuTianfu Wu

Abstract

Breast cancer is a major cause of mortality in women; however, technologies for early stage screening and diagnosis (e.g., mammography and other imaging technologies) are not optimal for the accurate detection of cancer. This creates demand for a more effective diagnostic means to replace or be complementary to existing technologies for early discovery of breast cancer. Cancer neoantigens could reflect tumorigenesis, but they are hardly detectable at the early stage. Autoantibodies, however, are biologically amplified and hence may be measurable early on, making them promising biomarkers to discriminate breast cancer from healthy tissue accurately. In this review, we summarized the recent findings of breast cancer specific antigens and autoantibodies, which may be useful in early detection, disease stratification, and monitoring of treatment responses of breast cancer.

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Citations

Jul 11, 2020·International Journal of Environmental Research and Public Health·Hye-Sun ByunGyung-Duck Kim
Jan 14, 2021·International Journal of Molecular Sciences·Hsing-Ju Wu, Pei-Yi Chu
Oct 25, 2020·Biosensors·Alma Rosa Oaxaca-CamachoRodolfo Hernández-Gutiérrez
Mar 7, 2021·Cancers·Hugo de JongeClaudia Scotti
Jul 17, 2020·Journal of Medicinal Chemistry·Pablo A Guillen-PozaFayna Garcia-Martin
Nov 7, 2021·Scientific Reports·Masaaki KubotaYasuo Iwadate

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Methods Mentioned

BETA
biopsy
glycosylation
enzyme-linked immunosorbent assay
ELISA
electrophoresis
Protein Profiling
biosensor

Software Mentioned

SERPA

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