PMID: 2507728Oct 1, 1989Paper

Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene

The Journal of Experimental Medicine
T LogtenbergF W Alt

Abstract

Little is known about the utilization of human Ig heavy chain variable gene segments (VH segments) in different B-lineage cell populations or in antibodies of particular specificity and function. We now demonstrate that human antibodies with Ig VH regions encoded by the most JH-proximal human VH segment (VH6) have specificities resembling those of autoantibodies present in sera of patients with systemic lupus erythematosus (e.g., anti-DNA and anticardiolipin). These specificities appear to be encoded by the germline VH6 gene because the activity was found in multiple independent VH6 antibodies in which the light chain varied with respect to isotype and V kappa subgroup. Features of CDR3 length and somatic mutation patterns in several VH6 antibodies suggested that they were selected by the immune system.

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Citations

Sep 1, 1990·Journal of Clinical Immunology·C A BonaG Kelsoe
May 1, 1990·Journal of Clinical Immunology·T Logtenberg
Apr 1, 1994·Molecular Immunology·R A InselE Marin
Oct 6, 1998·Journal of Immunological Methods·S Lacroix-DesmazesM D Kazatchkine
Aug 1, 1997·Immunology Today·G J Silverman
Oct 9, 1998·Clinical and Experimental Immunology·J RidingsH Zola
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·K N KasturiC A Bona
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·H J DitzelD R Burton
Dec 1, 1994·AIDS Research and Human Retroviruses·E M van der DonkR W van der Heijden
Mar 11, 1994·Nucleic Acids Research·Z Sun, G R Kitchingman
Mar 11, 1994·Nucleic Acids Research·Z Sun, G R Kitchingman
Jul 1, 1995·Scandinavian Journal of Immunology·M BørretzenK M Thompson
Aug 1, 1992·Immunological Reviews·A K StewartR S Schwartz
Apr 1, 1995·Immunological Reviews·D M Klinman, A D Steinberg
Apr 5, 1997·Annals of the New York Academy of Sciences·B D StollarY Hirabayashi
Feb 1, 1991·The Journal of Clinical Investigation·D A CarsonT J Kipps
May 1, 1991·The Journal of Clinical Investigation·A J Manheimer-LoryB A Diamond
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Jun 1, 1993·The Journal of Clinical Investigation·E H SassoE C Milner
Jul 1, 1995·The Journal of Clinical Investigation·G J SilvermanM Sasano
Mar 3, 2007·The Journal of Clinical Investigation·Eric Meffre, Jane E Salmon
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Jan 1, 1990·International Reviews of Immunology·J E Berman, F W Alt
Jan 1, 1992·International Reviews of Immunology·A CoutinhoA Grandien

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