Autoantibodies in chronic hepatitis C virus infection: impact on clinical outcomes and extrahepatic manifestations

BMJ Open Gastroenterology
Andrew J GilmanMindie H Nguyen

Abstract

To examine the role that autoantibodies (auto-abs) play in chronic hepatitis C virus (HCV) regarding demographics, presence of extrahepatic manifestations and long-term outcomes in a large US cohort. Auto-abs have been reported to be prevalent in patients with chronic HCV infection, but data on the natural history of these patients are limited. The study included 1556 consecutive patients with HCV without concurrent HIV and/or HBV who had testing for antinuclear antibody (ANA), antimitochondrial antibody (AMA), antismooth muscle antibody (ASMA) and/or antiliver kidney microsomal antibody (LKM). Primary outcomes included development of cirrhosis, hepatic decompensations, hepatocellular carcinoma (HCC), mortality and/or sustained virological response (SVR) to antiviral therapy. A total of 388 patients tested positive for any auto-ab (ANA 21.8%, ASMA 13.3%, AMA 2.2% and LKM 1.2%). Patients who tested positive versus negative were more likely to be women (29.3% vs 20.9%, p<0.001) and less likely to achieve SVR with most treated patients receiving interferon-based therapies (37.2% vs 47.1%, p=0.031). There was no difference between groups for baseline laboratory data, disease state or rate of extrahepatic manifestations (42.8% vs 45...Continue Reading

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Citations

Nov 14, 2019·Infectious Diseases·Jae Hyoung ImJin-Soo Lee
Dec 11, 2019·Immunological Investigations·Mohamed EmaraRamadan A El-Domany
Jan 15, 2021·Neuropediatrics·Francesco GavazziLaura Adang
Aug 22, 2021·Journal of Cardiovascular Translational Research·Lixia MaSamuel S Lee
Sep 30, 2021·Clinical Reviews in Allergy & Immunology·Francesca ColapietroElena Generali

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