PMID: 9179462Mar 1, 1997Paper

Autoantibodies in relation to residual insulin secretion in children with IDDM

Diabetes Research and Clinical Practice
Johnny Ludvigsson, S Hellström

Abstract

To elucidate whether autoantibodies can be used to predict the intensity of autoimmune beta-cell destruction, we determined both C-peptide and autoantibodies (islet cell antibodies (ICA), insulin autoantibodies (IAA), islet cell surface antibodies (ICSA) and antibodies to glutamic acid decarboxylase (GADA)). In 89 diabetic children and adolescents at diagnosis at the age of 1.2-16.6 years (mean +/- S.D., 9.0 +/- 4.5). Only 12/89 (14%) had no autoantibodies at diagnosis, while 2 patients (2%) had all 4 autoantibodies. There was a positive correlation between GADA and ICA (P < 0.01). At diagnosis 70% of the patients had GADA, most common in patients above the age of 8 years at diagnosis (P < 0.001), and with higher GAD-index in girls (P < 0.05). ICA was detected in 63%, most common in the older age groups (P = 0.04). ICSA seen in 22% of the patients as well as IAA (detected in 32%) were most common < 8 years of age (P = 0.06, P = 0.08, respectively). Children with autoantibodies had similar C-peptide levels through the follow up period as children of the same sex and age without antibodies, except for patients with ICSA alone or in combination with other autoantibodies who tended to have higher C-peptide levels. We conclude that ...Continue Reading

References

Mar 2, 1989·The New England Journal of Medicine·S C ShahN E Simpson
Mar 1, 1987·The Journal of Clinical Investigation·S BaekkeskovF Lindgren
Jan 1, 1981·The American Journal of Medicine·J Nerup, A Lernmark

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Citations

Apr 30, 2003·Diabetes·Pejman Hanifi-MoghaddamHubert Kolb
Apr 26, 2003·Journal of Pediatric Endocrinology & Metabolism : JPEM·Katarzyna KadzielaEwa Pańkowska
Jun 5, 2018·Pediatric Diabetes·Maaret TurtinenUNKNOWN Finnish Pediatric Diabetes Register

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