Autoantibodies specific to beta-2-microglobulin inhibit the Fc receptor-dependent phagocytosis of human monocytes

Immunology Letters
A FalusS Bozsóky

Abstract

Effect of anti-beta2-microglobulin (beta2m) antibodies was investigated on the in vitro Fc and C3 receptor dependent phagocytic capacity of human peripheral monocytes. Both rabbit and human anti-beta2m antibodies inhibit the Fc receptor-mediated phagocytosis. Anti-beta2m antibodies do not influence the spontaneous or C3b receptor-mediated ingestion. The inhibitory activity by human autoantibodies but not by rabbit anti-human beta2m antibodies was diminished when incubation was performed at 37 degrees C instead of 20 degrees C.

References

Jul 1, 1975·Cellular Immunology·C VincentJ P Revillard
Jun 1, 1977·Arthritis and Rheumatism·W P ArendG A Starkebaum
Nov 1, 1978·Medical & Biological Engineering & Computing·B A Coghlan, M G Taylor
Feb 1, 1979·Annals of the Rheumatic Diseases·M KávaiG Szegedi
Jan 1, 1976·Immunological Communications·K J Dorrington
Jan 1, 1974·Immunological Communications·R H PainterM D Poulik
Jan 1, 1980·Reviews of Infectious Diseases·P Elsbach
Aug 1, 1960·Archives of Biochemistry and Biophysics·A NISONOFFD L WOERNLEY

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.