PMID: 7516632May 31, 1994Paper

Autoantibodies to band 3 during aging and disease and aging interventions

Annals of the New York Academy of Sciences
M M KayJ R Goodman

Abstract

An aging antigen, senescent cell antigen, resides on the 911-amino acid membrane protein band 3. It marks cells for removal by initiating specific IgG autoantibody binding. Band 3 is a ubiquitous membrane transport protein found in the plasma membrane of diverse cell types and tissues, and in nuclear, mitochondrial, and golgi membranes. Band 3 in tissues such as brain performs the same functions as it does in red cells. Senescent cell antigen is generated on brain menbranes. Oxidation is a mechanism for generating senescent cell antigen. Neither cross-linking nor hemoglobin appears to play a role in generating senescent cell antigen. Although storage is the only in vitro model that mimics cellular aging in situ, we have discovered three alterations/mutations of band 3 that permit insight into aging in situ. One mutation with an addition to band 3 has normal or decelerated red cell aging. In contrast, another band 3 alteration with a suspected deletion or substitution that renders band 3 more susceptible to proteolysis, shows accelerated aging. The third alteration, which is also more susceptible to proteolysis, is associated with neurologic defects. Peptide technology was used to map the aging antigenic sites and anion transpor...Continue Reading

References

Jan 1, 1978·Journal of Supramolecular Structure·M M Kay
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M M Kay
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M M KayS F Schluter
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P JarolimS C Liu
Jul 1, 1991·Transfusion Medicine Reviews·M M KayG Bosman
Jan 1, 1991·Annals of the New York Academy of Sciences·M M Kay
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M M KayF B Lin
Dec 1, 1990·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·G J Bosman, M M Kay
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M M KayG Bosman
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M M KayC Lawrence
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J A SingerW S Walker
Jan 1, 1988·Annals of the New York Academy of Sciences·M M KayP Coleman
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M M KayP S Bassel
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T Saitoh, K R Dobkins
Sep 1, 1986·The American Journal of Physiology·V L SchusterM L Jennings
Jul 30, 1986·Brain Research·T Saitoh, K R Dobkins
Nov 1, 1985·Journal of Cellular Physiology·A ElgavishE Meezan
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M M KayP S Bassel
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M M Kay
Jan 1, 1982·Cell Biology International Reports·G BartoszJ Kedziora
Oct 1, 1984·British Journal of Haematology·W S WalkerC W Jackson
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M M KayV Rudloff
Sep 1, 1983·Cellular Immunology·N Khansari, H H Fudenberg
Jun 1, 1982·American Journal of Hematology·P YamP Spath
Nov 1, 1982·Mechanisms of Ageing and Development·G BartoszA Wasilewski

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Citations

Feb 1, 1997·Biological Trace Element Research·D A Clopton, P Saltman
Mar 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S A SukharevA I Gaziev
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·J E PoulinM B Kay
Dec 18, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Francesco MisitiBruno Giardina
Dec 15, 2010·International Journal of Molecular Sciences·Julien DelobelNiels Lion
Jun 19, 2004·The International Journal of Biochemistry & Cell Biology·Maria Elisabetta ClementiFrancesco Misiti
Dec 23, 2006·The International Journal of Biochemistry & Cell Biology·M Elisabetta ClementiFrancesco Misiti
Feb 9, 2017·European Journal of Clinical Investigation·Cristiana Carelli-Alinovi, Francesco Misiti
Mar 27, 2004·The Journal of Biological Chemistry·Quansheng Zhu, Joseph R Casey
Nov 5, 2016·Clinical Hemorheology and Microcirculation·Cristiana Carelli-AlinoviFrancesco Misiti
Nov 26, 2002·The Journal of Biological Chemistry·Quansheng ZhuJoseph R Casey
Dec 18, 2002·Journal of Neuropathology and Experimental Neurology·Thor D SteinRonald E Kalil
Sep 12, 2017·Frontiers in Aging Neuroscience·Cristiana Carelli-Alinovi, Francesco Misiti
Aug 20, 2020·Mechanisms of Ageing and Development·Luca MassaccesiMassimiliano Marco Corsi Romanelli
Nov 26, 2009·Journal of Proteomics·Niels LionJean-Daniel Tissot

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