PMID: 4886046Apr 1, 1969Paper

Autoantibodies to colon in germfree rats monocontaminated with Clostridium difficile

The Journal of Experimental Medicine
S HammarströmR Lagercrantz

Abstract

Germfree rats monocontaminated with the anaerobic microorganisms Clostridium difficile or another Clostridium species (strain G 62) produce auto-antibodies to colon antigen. The antigen can be extracted with phenol water from the feces of germfree rats. Antibodies, demonstrable by means of passive hemagglutination of antigen sensitized sheep erythrocytes appear after monocontamination for 35 days or longer. The indirect immunofluorescence techniques, applied to sections of germfree rat colon, gave positive mucosal staining. The staining was similar to that obtained with sera from patients with ulcerative colitis or from rats immunized with rabbit colon. No antibodies were found in the sera of germfree rats, germfree rats monocontaminated with various other bacteria, conventional rats of germfree origin, or conventional Sprague-Dawley rats. Although the anti-colon antibodies of the Clostridium infected rats reacted with the same feces extract as the antibodies of ulcerative colitis patients or of rabbit colon immunized rats, their specificity was different. While the latter cross-react with polysaccharide from E. coli O14, those from the Clostridium-infected exgermfree rats did not. Rats monocontaminated with Cl. difficile also ...Continue Reading

References

Dec 1, 1968·The Journal of Experimental Medicine·R LagercrantzB E Gustafsson
Feb 1, 1966·Gut·R Wright, S C Truelove
Dec 1, 1960·The Journal of Experimental Medicine·B E GUSTAFSSON, L S LANKE
Nov 1, 1959·The Journal of Experimental Medicine·O BROBERGER, P PERLMANN
Jul 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·B J SKELLYJ TANAMI
Feb 1, 1965·The Journal of Experimental Medicine·G LINDSTEDTB E GUSTAFSSON
Jan 13, 1962·Nature·H RINDERKNECHT
Jul 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·P PerlmannD Campbell

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Citations

Jan 1, 1975·Immunological Communications·A C Wang, H H Fudenberg
Apr 4, 2021·Pathogens·Ales Macela, Klara Kubelkova
Mar 1, 1983·Infection and Immunity·C J CzuprynskiT Wilkins

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