Autoantibodies to each protein fraction extracted from cerebral endothelial cell membrane in the sera of patients with multiple sclerosis.

Journal of Neuroimmunology
N TsukadaA Okano

Abstract

Damage to the blood-brain barrier (BBB) occurs in multiple sclerosis (MS), probably due to an immunological mechanism. Anti-endothelial cell antibodies may play a pathogenetic role in the BBB damage. Our previous studies led us to search for which protein fraction extracted from cerebral endothelial cell membrane was reactive to antibodies in the sera of patients with MS. The antibodies to each protein fraction extracted from the rat cerebral endothelial cell membrane were studied in patients with MS, other neurological diseases and controls using an enzyme-linked immunosorbent assay (ELISA) method. The patients with active relapsing MS (P less than 0.01) displayed significantly higher levels of immunoglobulin G (IgG) binding to the endothelial cell membrane fraction than did the controls. The sera of the same patients (P less than 0.001) also showed significantly higher levels of antibodies to fraction I (8.0 kDa) than did the normal controls. The high levels of IgG binding to fraction II (11.0 kDa) and III (12.3 kDa) were significantly increased in the sera of patients with active relapsing MS compared to normal controls (P less than 0.01). The immune response to the protein fraction extracted from the cerebral endothelial ce...Continue Reading

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Citations

Mar 1, 1991·Journal of the Neurological Sciences·M MatsudaN Yanagisawa
Aug 1, 1991·Journal of the Neurological Sciences·N TsukadaK Yone
Jul 1, 1993·Journal of the Neurological Sciences·N TsukadaN Yanagisawa
Aug 26, 2004·Kidney International·Carolina HolménSuchitra Sumitran-Holgersson
Oct 1, 1992·Acta Neurologica Scandinavica·B E SouberbielleW C Russell
Jan 22, 2009·Journal of Neuroinflammation·Lawrence L HorstmanAlireza Minagar
Jan 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Natalia A PonomarenkoAlexander G Gabibov

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