PMID: 11921417Mar 29, 2002Paper

Autoantibodies to GAD, IA-2 and insulin in ICA-positive first-degree relatives of children with type 1 diabetes: a comparison between parents and siblings

Diabetes/metabolism Research and Reviews
Sari KorhonenFinnish Study Group for ICA Screening

Abstract

Islet cell antibodies (ICA) represent a heterogenous group of autoantibodies to diabetes-associated antigens, including glutamic acid decarboxylase (GAD) and the IA-2 protein. The objectives of the present study were to compare the prevalence of autoantibodies to known biochemically characterized autoantigens between ICA-positive non-diabetic parents and siblings of children with type 1 diabetes and to evaluate how such antibodies explain ICA reactivity. The presence and levels of GAD antibodies (GADA), IA-2 antibodies (IA-2A) and insulin autoantibodies (IAA) were analyzed in the sera of 184 ICA-positive first-degree relatives (79 parents and 105 siblings). The prevalences of GADA (61.9% in siblings vs 32.9% in parents), IA-2A (55.2% vs 15.2%) and IAA (41.0% vs 0%) were increased among ICA-positive siblings relative to ICA-positive parents (p<0.001). The siblings had higher ICA titers (p<0.001) than the parents but tended to have lower GADA levels (p=0.12). IA-2A levels did not differ between the two groups. IA-2A levels explained a higher proportion of the ICA reactivity in the siblings than in the parents (44% vs 12%, p=0.004), and GADA levels had the same tendency (27% vs 10%, p=0.11). In a multiple regression analysis, GADA...Continue Reading

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Citations

May 25, 2010·Seminars in Immunopathology·Patrick A RoweMark A Atkinson
Dec 9, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Juha Grönholm, Michael J Lenardo
Dec 30, 2004·Diabetes/metabolism Research and Reviews·Xaio-Ping WangF Charles Brunicardi
Oct 24, 2019·World Journal of Diabetes·Michael Adeyemi Olamoyegun, Oluwabukola Ayodele Ala
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peggy L KendallJames W Thomas

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