Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL

Clinical and Experimental Immunology
H H HandleyJ H Vaughan

Abstract

The 65-kD hsp from Mycobacterium tuberculosis has been reported to induce an autopathogenic subset of T cells in at least two animal models of autoimmune disease. Reports of increased expression of human hsp60 in the inflamed synovial tissue of rheumatoid arthritis (RA) patients, increased proliferation of RA synovial fluid T cells to mycobacterial hsp65, and increased levels of anti-mycobacterial hsp65 antibody in synovial fluid, have suggested that the highly homologous human (hu) hsp60 may be recognized as an autoantigen iin RA patients. In the present study, we have examined by ELISA the serum IgG antibody levels to mycobacterial hsp65 and hu hsp60, as well as to the Escherichia coli hsp60, groEL, in patients with RA, systemic lupus erythematosus (SLE), Reiter's syndrome, active tuberculosis, and normal controls. In all these groups, the levels of anti-groEL and anti-hu hsp60 were significantly higher than the anti-mycobacterial hsp65. Anti-hu hsp60 was positively correlated with anti-groEL, but not with anti-mycobacterial hsp65. Anti-hu hsp60 was competitively inhibited by either soluble groEL or hu hsp60, but little or none by mycobacterial hsp65. Reiter's sera were found to have somewhat higher levels of anti-groEL and a...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Aug 1, 1992·Journal of Autoimmunity·M G DanieliA Gabrielli
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D EliasI R Cohen
Oct 1, 1987·Immunological Reviews·A Lanzavecchia
Jan 1, 1988·Annual Review of Genetics·S Lindquist, E A Craig
Feb 1, 1989·Annals of the Rheumatic Diseases·G TsoulfaP M Lydyard
Sep 11, 1987·Cell·M B Oldstone
Jan 1, 1984·The Journal of Clinical Investigation·J HoloshitzI R Cohen
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·H UdonoP K Srivastava

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Citations

Jan 1, 2000·Arthritis and Rheumatism·S BlässG R Burmester
May 20, 2000·Biotechnology & Genetic Engineering Reviews·A R CoatesP Mascagni
Jan 9, 2007·Clinical Rheumatology·Taha Rashid, Alan Ebringer
Jan 12, 2008·Clinical Reviews in Allergy & Immunology·Jean-Eric AlardChristophe Jamin
Jun 24, 2020·Arthritis Research & Therapy·Aijing LiuAntonio La Cava
Oct 19, 1999·DNA Sequence : the Journal of DNA Sequencing and Mapping·H I Reid, M P Riggio
Mar 31, 2006·Thyroid : Official Journal of the American Thyroid Association·Salvatore BenvengaFabrizio Guarneri
Jan 26, 2021·Journal of Translational Autoimmunity·Michael Battaglia, Lee Ann Garrett-Sinha
Sep 1, 1997·Molecular and Biochemical Parasitology·A DasN Kumar

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