Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives

Diabetologia
P AchenbachENDIT Group

Abstract

The aim of this study was to evaluate the prognostic significance of autoantibodies to IA-2beta (IA2betaA) in a large, well-characterised population of islet cell antibody (ICA)-positive relatives followed for 5 years in the European Nicotinamide Diabetes Intervention Trial. Autoantibodies to insulin (IAA), glutamate decarboxylase (GADA) and IA-2 (IA2A) were measured in 549 participants at study entry, and IA2A-positive samples tested for IA2betaA. First-phase insulin response (FPIR) and oral glucose tolerance were determined at baseline. Of 212 ICA/IA2A-positive participants (median age 12.1 years; 57% male), 113 developed diabetes (5 year cumulative risk 56%), and 148 were also GADA-positive and IAA-positive (4Ab-positive). IA2betaA were detected in 137 (65%) ICA/IA2A-positive participants and were associated with an increased 5 year diabetes risk (IA2betaA-positive 65 vs 39% in IA2betaA-negative, p=0.0002). The effect was most marked in 4Ab-positive relatives (72% vs 52%, p=0.003). Metabolic testing further refined risk assessment. Among 101 4Ab-positive relatives with IA2betaA, the 5 year risk was 94% in those with a low FPIR (vs 50% in those with a normal FPIR, p<0.0001), and 95% in those with impaired glucose tolerance (I...Continue Reading

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Citations

Jun 11, 2008·Immunologic Research·Bo Wang, Roland Tisch
Dec 5, 2008·Immunologic Research·Bo Wang, Roland Tisch
Nov 1, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Stephanie KrausePeter Achenbach
Jun 19, 2013·Pediatric Diabetes·Hilary R Thomas, Stephen E Gitelman
Nov 16, 2010·Journal of Diabetes·Li Zhang, George S Eisenbarth
Apr 27, 2016·Current Diabetes Reports·Vito Lampasona, Daniela Liberati
Sep 20, 2011·Diabetes Care·Michael SchlosserUNKNOWN Participating Laboratories
Aug 13, 2011·Diabetes·Liping YuUNKNOWN Type 1 Diabetes TrialNet Anti-CD20 Study Group
Dec 30, 2008·Advances in Immunology·Sue TsaiPere Santamaria
Nov 7, 2016·Diabetologia·Christine von ToerneStefanie M Hauck
Apr 29, 2008·Arquivos brasileiros de endocrinologia e metabologia·George S Eisenbarth, Joy Jeffrey
Aug 10, 2019·Clinical and Experimental Immunology·E Bonifacio, P Achenbach
Sep 11, 2009·Diabetes Care·Tihamer OrbanUNKNOWN Diabetes Prevention Trial-Type 1 Study Group
Apr 22, 2021·Endocrine Reviews·Michelle SoCarla J Greenbaum

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