PMID: 7544246Aug 1, 1995Paper

Autoantibodies to malondialdehyde-modified epitope in connective tissue diseases and vasculitides

Clinical and Experimental Immunology
A AmaraM Geffard

Abstract

Malondialdehyde (MDA), a peroxidative end-product released during polyunsaturated fatty acid degradation, reacts strongly with lysine residues of cellular proteins. MDA-modified proteins become immunogenic and may elicit specific autoantibody formation. We hypothesized that systemic diseases in which inflammatory events occur, could be an interesting model for studying oxidative stress. A few studies have suggested that MDA-modified proteins may exist in systemic diseases, and that autoantibodies to MDA-modified structures might reflect this oxidative process. Autoantibodies to MDA-modified epitope(s) were therefore assayed in sera of patients with systemic lupus erythematosus (SLE, n = 29), scleroderma (SCL, n = 11), giant cell arteritis (GCA, n = 11), periarteritis nodosa (PAN, n = 10), rheumatoid arthritis (RA, n = 9), and healthy subjects (HS, n = 32). Significantly increased anti-MDA-modified epitope(s) autoantibodies were found in patients with SLE and also in other systemic diseases such as PAN and SCL. Autoantibodies to MDA-modified epitope(s) were predominantly of IgM isotype, with low levels of IgG and no IgA activity. In SLE, anti-MDA-modified epitope(s) autoantibody titres correlated strongly with systemic lupus act...Continue Reading

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Citations

Jan 15, 2005·Antioxidants & Redox Signaling·Robert G Salomon
Jan 25, 2005·Microbiology and Immunology·Rie KarasawaTomohiro Kato
Oct 5, 2010·Mediators of Inflammation·Daniela BraconiAnnalisa Santucci
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