Autoantibodies to mitochondrial and centromere antigens in primary biliary cirrhosis and systemic sclerosis

Clinical and Experimental Immunology
N J McHughP J Maddison

Abstract

High levels of IgG antibodies to the multi-enzyme complex bovine pyruvate dehydrogenase (PDHC) were detected by a sensitive ELISA in all patients with histologically proven primary biliary cirrhosis (PBC), in a minority of patients with systemic sclerosis without overt PBC or with chronic liver diseases of another cause and in no rheumatoid arthritis or normal controls. Most (15/21) but not all of these positive patients recognized a 70-kD (E2) component of PDHC on immunoblotting. Additional recognition of a centromere-associated 140-kD polypeptide was associated with the presence of scleroderma-like features (Raynaud's phenomenon and sclerodactyly) in PBC, further emphasizing the serological and clinical overlap between these two conditions.

References

Feb 1, 1978·Annals of the Rheumatic Diseases·A K ClarkeR Williams
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Lindenborn-FotinosP A Berg
May 25, 1989·The New England Journal of Medicine·J Van de WaterM E Gershwin
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R L CoppelM E Gershwin
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S P FusseyS J Yeaman
Feb 1, 1986·The Journal of Clinical Investigation·W EarnshawN Rothfield
Aug 1, 1970·British Medical Journal·I M Murray-LyonR Williams
Mar 1, 1971·The American Journal of Medicine·T B ReynoldsR L Peters
Jul 1, 1983·Arthritis and Rheumatism·D MakinenS Sherlock
Dec 1, 1982·Annals of the Rheumatic Diseases·R M BernsteinR Williams

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Citations

Mar 14, 2007·Zeitschrift für Rheumatologie·R MierauE Genth
Jan 1, 1993·Autoimmunity·S A Jimenez, O Batuman
Aug 1, 1995·Liver·C CostaA Murgia
May 1, 1992·Journal of Clinical Immunology·N ZurgilC Luderschmidt
May 14, 2010·Digestive Diseases and Sciences·Albert J Czaja
Jan 1, 1995·International Reviews of Immunology·D Vázquez-Abad, N F Rothfield
Jun 28, 2002·Pathologie-biologie·Nicole Fabien, Hugues Rousset

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