Autoantibodies to oxidised low density lipoproteins in IDDM are inversely related to metabolic control and microvascular complications

Diabetologia
A FestaE J Menzel

Abstract

Diabetes mellitus is associated with an increased risk of atherosclerosis. The oxidation of low-density lipoproteins (LDL) is considered a key event in the initiation of atherosclerosis. To investigate LDL oxidation in vivo we measured autoantibodies to oxidised LDL (oxLDL) in 94 patients with insulin-dependent diabetes mellitus (IDDM), compared to 27 age-matched, healthy control subjects. Patients and control subjects were screened for autoantibodies using a solid phase ELISA, comparing the binding to oxLDL with that to native LDL (nLDL). In patients with IDDM the oxLDL/nLDL antibody ratio was significantly higher than in control subjects (means+/-SEM: 2.24+/-0.26 vs 1.17+/-0.17, p < 0.03). Antibody-negative patients had a longer diabetes duration (13.5+/-1.3 vs 9.1+/-1.1 years, p < 0.01) and higher actual and mean HbA1c levels compared to antibody-positive patients (8.8+/-0.2 vs 7.9+/-0.2%, p < 0.005 and 8.3+/-0.2 vs 7.7+/-0.2%, p < 0.03; respectively). In patients with a high microangiopathy score, the antibody ratio was lower than in patients without complications (1.04+/-0.10 vs 2.40+/-0.29, p < 0.01). OxLDL specific immune complexes were found exclusively in antibody-negative as compared to antibody-positive patients (18....Continue Reading

Citations

Mar 2, 2005·Irish Journal of Medical Science·G H Tomkin
Oct 30, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nurcan CengizMehmet Haberal
Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·Z TurkB Benko
Sep 6, 2002·Diabetes Research and Clinical Practice·Noriko UjiharaYasuhiko Iwamoto
Feb 3, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·J H PinkneyC H Bolton
Jun 8, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C H BoltonJ H Pinkney
Sep 25, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Meinrad LindschingerWillibald Wonisch
Jun 14, 2008·Clinical & Developmental Immunology·Natalia MiliotiErnesto Oviedo-Orta
May 12, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Maria F Lopes-Virella, Gabriel Virella
Jun 3, 2008·Atherosclerosis·Gabriel Virella, Maria F Lopes-Virella
Jun 6, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Gabriel VirellaMaria F Lopes-Virella
Oct 2, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Josefa GironaLluís Masana
Jul 23, 2005·Annals of the New York Academy of Sciences·Maria F Lopes-VirellaGabriel Virella
Apr 30, 2009·Proteomics·Matthew R RichardsonFrank A Witzmann
Mar 11, 1999·Journal of Receptor and Signal Transduction Research·G SobalE J Menzel
Jul 9, 2008·Atherosclerosis·Michelle A MillerFrancesco P Cappuccio
Mar 1, 2005·Diabetes Care·Francesco PiarulliDomenico Fedele
May 15, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Tuula JanatuinenOlli T Raitakari
Apr 1, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Vincent van WeelPaul H A Quax
Mar 15, 2019·Journal of Atherosclerosis and Thrombosis·Hiroyasu YamamotoShinji Kihara
Jul 11, 2003·Clinical and Diagnostic Laboratory Immunology·Gabriel Virella, Maria F Lopes-Virella
Mar 26, 2003·Coronary Artery Disease·Edgar R MillerJerilyn K Allen
May 11, 2005·The American Journal of Clinical Nutrition·Didier QuilliotOlivier Ziegler
Mar 29, 2020·Trends in Endocrinology and Metabolism : TEM·Bruno Vergès
Mar 18, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M F Lopes-VirellaK Y Forrest
Dec 18, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·G VirellaUNKNOWN DCCT/EDIC Research Group

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