Autoantibodies to p53 in ovarian cancer patients and healthy women: a comparison between whole p53 protein and 18-mer peptides for screening purposes

Cancer Letters
C J VennegoorP Kenemans

Abstract

Autoantibodies against complete p53 protein and 18-mer peptides of p53 in ovarian cancer patients and healthy women were examined. Sera from 9% (4/46) of ovarian cancer patients but none (0/51) of healthy women recognized complete p53 protein. The antibodies were mainly of the IgG1 isotype. Two patients had also IgG2 antibodies. Sera from 28% (13/46) of cancer patients and 21% (11/52) of healthy women contained either IgM, or IgM plus IgG2 antibodies against 18-mer p53 peptides. Screening against complete p53 protein instead of peptides seems necessary for identifying patients with tumor-related antibodies. IgG2 antibodies against p53 suggest p53-specific CD4+ T helper 1 cell activity in some of the ovarian cancer patients.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A M DavidoffJ R Marks
Mar 1, 1992·The Journal of Pathology·R VilluendasP Martinez
Mar 1, 1991·European Journal of Immunology·V LeyE L Larsson-Sciard
Aug 1, 1989·Journal of Clinical Pathology·M A GreenA D Pearson
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H MasudaM J Cline
Sep 20, 1995·Journal of the National Cancer Institute·G E TriversC C Harris
Feb 1, 1995·Journal of Assisted Reproduction and Genetics·A BukovskyS E van Meter
Oct 1, 1994·Current Biology : CB·T R Hupp, D P Lane
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y NoguchiL J Old
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y NoguchiL J Old
Aug 15, 1994·International Journal of Cancer. Journal International Du Cancer·K AngelopoulouP S Bunting
May 1, 1994·Immunology Letters·H W NijmanC J Melief
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J KupryjańczykD W Yandell
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·M TheobaldL A Sherman

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Citations

Jun 6, 2003·Cancer Detection and Prevention·S SangrajrangT Soussi
Aug 9, 2005·Journal of Proteome Research·Karen S Anderson, Joshua LaBaer
Feb 8, 2003·Hybridoma and Hybridomics·Irena KirmanIlya Trakht
Mar 4, 1998·Current Opinion in Obstetrics & Gynecology·W P CollinsS Campbell
Jul 9, 2008·Biochemistry. Biokhimii︠a︡·P V BelousovS A Nedospasov
Sep 17, 2005·Journal of Translational Medicine·H W NijmanT Daemen
Apr 29, 2009·Gynecologic Oncology·Miyun Tsai-TurtonRichard B S Roden
May 13, 2009·European Journal of Cancer Care·S KumarR Guleria
Aug 4, 2009·Gynecologic Oncology·Douglas D TaylorLynn P Parker
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E V FedoseyevaG Benichou
Jun 4, 2010·Expert Review of Vaccines·Silvia von Mensdorff-Pouilly
Jun 12, 2020·International Journal of Molecular Sciences·Navid SobhaniYong Li

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