Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis

Gerontology
Antonella LisaAnna Ivana Scovassi

Abstract

Centenarians display a characteristic autoantibody profile, this being the absence of organ-specific autoantibodies and an increase in non-organ-specific autoantibodies without any full-blown autoimmune disease. Antibodies directed to the nuclear protein poly(ADP-ribose) polymerase (PARP) were frequently found in the sera of patients affected by autoimmune diseases. This study aims at investigating the presence of circulating autoantibodies directed against PARP-1 in normal subjects, and searching for a possible correlation between level of circulating autoantibodies and age. The presence of antibodies to PARP was monitored by ELISA according to a previously developed protocol. Data were analysed by parametric statistics (unpaired t test, chi(2) test). Our study performed on 33 centenarians and 66 subjects of age ranging from 12 to 80 years shows that circulating autoantibodies to the nuclear enzyme PARP, previously described in autoimmune diseases, are present in the sera of normal healthy people and increase with age. Taking into account the role of PARP-1 in DNA damage and apoptosis, the data are compatible with Grabar's hypothesis, which proposed several decades ago that 'autoreactive antibodies represent a physiological sy...Continue Reading

Related Concepts

Senility
Antibody Specificity
Autoantibodies
Longevity
Tissue Specificity
Autoimmune Diseases
DNA Damage
Enzyme-Linked Immunosorbent Assay
Laboratory Procedures
Metabolism

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Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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