PMID: 7543596Sep 1, 1995Paper

Autoantibodies to prostate specific antigen in patients with benign prostatic hyperplasia

The Journal of Urology
A ZismanE Mozes

Abstract

We tested for a possible autoimmune process in benign prostatic hyperplasia (BPH). Titers of IgG antibodies to prostate specific antigen (PSA) were measured in the sera of 85 BPH patients, 20 controls and 17 chronic prostatitis patients by enzyme-linked immunosorbent assay. The mean anti-PSA titers in the BPH group were significantly higher than in the controls and prostatitis group (p < 0.0005). Accordingly, 59% of BPH patients could be defined as responders to PSA compared to none among the controls (p < 0.0005). Circulating autoantibodies to PSA were shown to exist in the sera of BPH patients. This observation suggests that autoimmune processes may have a role in BPH.

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Citations

Aug 1, 2002·Current Urology Reports·Robert M Moldwin
Jul 29, 2003·Current Urology Reports·Caroline Maake, Hubert John
Mar 10, 2001·Journal of Chemotherapy·S ScelziM Rizzo
Dec 22, 2006·European Urology·Gero KramerMichael Marberger
Jun 11, 2009·International Journal of Andrology·B FibbiM Maggi
May 19, 2010·Expert Review of Clinical Immunology·Giuseppe PennaLuciano Adorini
Jul 4, 2001·The Journal of Urology·I M KeithT D Moon
Aug 19, 2007·Neurourology and Urodynamics·K-E Andersson
May 15, 2013·Nature Reviews. Urology·Panikar Wadhera
Aug 2, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Noémie LautenbachCédric Poyet

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