PMID: 9165272Jan 1, 1996Paper

Autoantibodies to T-cell receptor beta chains in human heart transplantation: epitope and spectrotype analyses and kinetics of response

Experimental and Clinical Immunogenetics
J J MarchalonisN Suciu-Foca

Abstract

Autoantibodies against T-cell receptors have been found in two alloimmunization situations in humans: renal transplantation and pregnancy. We carried out longitudinal studies of human heart transplant recipients monitoring their autoantibody production to a recombinant single chain T-cell receptor V alpha/V beta construct, a set of nested, overlapping peptides duplicating the complete covalent structure of an individual T-cell receptor beta chain and a set of peptides duplicating the first complementarity determining segments of 24 distinct human V beta gene products in order to define the time course, epitope specificity and recognition heterogeneity of the response. Autoantibodies against intact and peptide-defined V beta and C beta determinants were generated following human heart allotransplantation. The responses generally show an increase following transplantation that subsequently decreases with time, a result which is consistent with a single immunization. However, some patients showed elevated responses as long as 12 months following the transplant. Autoantibody anti-CDR1 spectrotype analyses detected individual differences among patients, but 5 of 8 patients characterized in detail showed elevated IgG binding to CDR1 ...Continue Reading

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