Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report.

Nature Metabolism
Tim HollsteinMatthias Laudes


Here we report a case where the manifestations of insulin-dependent diabetes occurred following SARS-CoV-2 infection in a young individual in the absence of autoantibodies typical for type 1 diabetes mellitus. Specifically, a 19-year-old white male presented at our emergency department with diabetic ketoacidosis, C-peptide level of 0.62 µg l-1, blood glucose concentration of 30.6 mmol l-1 (552 mg dl-1) and haemoglobin A1c of 16.8%. The patient´s case history revealed probable COVID-19 infection 5-7 weeks before admission, based on a positive test for antibodies against SARS-CoV-2 proteins as determined by enzyme-linked immunosorbent assay. Interestingly, the patient carried a human leukocyte antigen genotype (HLA DR1-DR3-DQ2) considered to provide only a slightly elevated risk of developing autoimmune type 1 diabetes mellitus. However, as noted, no serum autoantibodies were observed against islet cells, glutamic acid decarboxylase, tyrosine phosphatase, insulin and zinc-transporter 8. Although our report cannot fully establish causality between COVID-19 and the development of diabetes in this patient, considering that SARS-CoV-2 entry receptors, including angiotensin-converting enzyme 2, are expressed on pancreatic β-cells and,...Continue Reading


Apr 1, 1994·Immunology Today·B Fleischer
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Jian WangLiping Yu
Jul 5, 2012·Cold Spring Harbor Perspectives in Medicine·Mikael Knip, Olli Simell
Oct 30, 2014·African Health Sciences·Chukwuma O EkpebeghErnesto Blanco-Blanco
Sep 22, 2015·American Journal of Physiology. Endocrinology and Metabolism·Robin ShoemakerLisa Cassis
Aug 6, 2016·Autoimmunity Reviews·Teresa Rodriguez-CalvoMatthias G von Herrath
Oct 19, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Marie AmorosoBernard Rees Smith
Jan 29, 2020·JAMA : the Journal of the American Medical Association·Anette-Gabriele ZieglerUNKNOWN Fr1da Study Group
Feb 14, 2020·Tropical Medicine & International Health : TM & IH·Thirumalaisamy P Velavan, Christian G Meyer
Apr 27, 2020·The Lancet. Diabetes & Endocrinology·Stefan R BornsteinBarbara Ludwig
Apr 28, 2020·Diabetes Research and Clinical Practice·Ying Jie CheeEster Yeoh
Apr 30, 2020·Nature Reviews. Immunology·Matthew Zirui TayLisa F P Ng
May 4, 2020·Diabetes Research and Clinical Practice·Gianluca IacobellisErnesto Bernal Mizrachi
May 31, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Heleia Roca-HoMarta Riera
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