PMID: 9156642Feb 1, 1997Paper

Autoantibody pattern in scleritis and episcleritis

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
M ZierhutH J Thiel


Episcleritis and scleritis can be caused by various systemic disorders, which can be triggered by infectious diseases. We studied the autoantibody pattern against various organ-specific and non-organ-specific antigens in episcleritis and scleritis patients. Sera from 46 patients (episcleritis n = 28, scleritis n = 18) were studied for antibodies against nuclei, smooth muscle cells, mitochondria, endothelial cells, sarcolemma, liver cells, heart muscle fibrils, parietal cells and thyroid cells by immunofluorescence testing. Titers of antibodies against thyroglobulin, laminin, keratin and microsomes were evaluated by ELISA. In patients with episcleritis the pattern of autoantibodies found was different from that in scleritis patients. Thus, in episcleritis the levels of antibodies against sarcolemma (32%), parietal cells (25%), laminin (38%), keratin (58%) and microsomes (28%) were elevated, while scleritis patients, besides keratin antibodies (50%), demonstrated anti-nuclear antibodies (ANA) in 28% of cases. These differences were not significant. Approximately 5% of normal control patients show these antibodies. Previous studies have shown that episcleritis rarely develops into scleritis. Our results suggest that this may be du...Continue Reading


Dec 6, 2001·Current Opinion in Ophthalmology·C E Pavesio, F M Meier
Jan 15, 2008·Veterinary Ophthalmology·M J DayW J Carter

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