Abstract
To study the profile of autoantibodies on long-term follow-up of children with Kawasaki disease (KD). In this single-center observational cohort study, 50 children who had been diagnosed and treated for KD with a minimum follow-up period of 3 years were enrolled. The organ-specific autoantibodies that were assessed in the study included anti-thyroid microsomal antibody (TMA), anti-parietal cell antibody (PCA) and anti-liver kidney microsomal (LKM) antibody. The organ-nonspecific autoantibodies that were studied included anti-endothelial cell antibody (AECA), anti-nuclear antibody (ANA), anti-neutrophil cytoplasmic antibody (ANCA), anti-mitochondrial antibody (AMA) and anti-smooth muscle antibody (SMA). The sample for assessment of serology was taken at a mean follow-up period of 6.41 years (±1.95 SD) after diagnosis. Autoantibodies were detected in 11/50 (22%) patients. ANA was detected in three patients, TMA was positive in seven and ANCA was positive in one. These autoantibodies likely develop in children with KD during the acute stage and may persist for many years. There is no concrete evidence to suggest that these children are at increased risk of developing an autoimmune disease in the future. However, there is some just...Continue Reading
References
Jul 1, 1978·Medical Education·R J Markert
Dec 1, 1992·The Journal of Pediatrics·C Y LinB Chiang
Mar 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E SoppiP Pelkonen
Mar 1, 1989·Archives of Disease in Childhood·C O SavageM J Dillon
Jan 1, 1986·The American Journal of Pediatric Hematology/oncology·N J BuninD B Sullivan
Nov 6, 1993·Lancet·W G Phillips
Jun 1, 1994·The Journal of Pediatrics·J GuzmanR E Petty
Jan 1, 1989·International Reviews of Immunology·D Y Leung
Apr 7, 1999·American Journal of Clinical Pathology·J SavigeA Wiik
Jul 27, 2001·The American Journal of Cardiology·A M McMorrow TuohyL L Minich
Jul 30, 2002·Cardiology·Monesha GuptaThomas J A Lehman
Oct 7, 2004·Journal of Hepatology·Diego VerganiUNKNOWN International Autoimmune Hepatitis Group
Oct 27, 2004·Circulation·Jane W NewburgerUNKNOWN American Academy of Pediatrics
Nov 26, 2005·Rheumatology International·R VenkatramanR W Minz
Jan 19, 2006·Rheumatology·S StagiF Falcini
Apr 20, 2007·Journal of General Internal Medicine·Anne E WolffLaura Zakowski
Oct 1, 2011·Lupus·J C DinizC A Silva
Feb 1, 2012·Autoimmunity·Christiane S Hampe
Apr 12, 2013·Journal of Gastroenterology·Hirotsugu ImaedaAkira Andoh
Apr 8, 2015·Indian Pediatrics·Dhwanee ThakkarAnupam Sachdeva
Apr 9, 2016·Journal of the American College of Cardiology·Jane W NewburgerJane C Burns
Sep 4, 2016·Expert Review of Clinical Immunology·Shreya Agarwal, Devendra K Agrawal
Mar 31, 2017·Circulation·Brian W McCrindleUNKNOWN American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Di
Oct 13, 2017·Clinical and Vaccine Immunology : CVI·Anne E Tebo
Citations
Jan 25, 2020·European Journal of Pediatrics·Sandesh GuleriaSurjit Singh
Jun 5, 2019·BMC Immunology·Meng XuSirui Yang
Mar 3, 2020·Frontiers in Pediatrics·Ankur Kumar JindalSurjit Singh
Jan 26, 2021·Frontiers in Pediatrics·Po-Yu HuangHo-Chang Kuo
Aug 29, 2019·Expert Review of Clinical Immunology·Ankur Kumar JindalSurjit Singh
Mar 17, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mindy S Lo
Mar 18, 2020·Genes & Diseases·Kanika AroraSurjit Singh