Autoantibody profile in children with Kawasaki disease on long-term follow-up: A prospective study from North India

International Journal of Rheumatic Diseases
Aseem BashaSurjit Singh

Abstract

To study the profile of autoantibodies on long-term follow-up of children with Kawasaki disease (KD). In this single-center observational cohort study, 50 children who had been diagnosed and treated for KD with a minimum follow-up period of 3 years were enrolled. The organ-specific autoantibodies that were assessed in the study included anti-thyroid microsomal antibody (TMA), anti-parietal cell antibody (PCA) and anti-liver kidney microsomal (LKM) antibody. The organ-nonspecific autoantibodies that were studied included anti-endothelial cell antibody (AECA), anti-nuclear antibody (ANA), anti-neutrophil cytoplasmic antibody (ANCA), anti-mitochondrial antibody (AMA) and anti-smooth muscle antibody (SMA). The sample for assessment of serology was taken at a mean follow-up period of 6.41 years (±1.95 SD) after diagnosis. Autoantibodies were detected in 11/50 (22%) patients. ANA was detected in three patients, TMA was positive in seven and ANCA was positive in one. These autoantibodies likely develop in children with KD during the acute stage and may persist for many years. There is no concrete evidence to suggest that these children are at increased risk of developing an autoimmune disease in the future. However, there is some just...Continue Reading

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Citations

Jan 25, 2020·European Journal of Pediatrics·Sandesh GuleriaSurjit Singh
Mar 3, 2020·Frontiers in Pediatrics·Ankur Kumar JindalSurjit Singh
Jan 26, 2021·Frontiers in Pediatrics·Po-Yu HuangHo-Chang Kuo
Aug 29, 2019·Expert Review of Clinical Immunology·Ankur Kumar JindalSurjit Singh
Mar 17, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mindy S Lo
Mar 18, 2020·Genes & Diseases·Kanika AroraSurjit Singh

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