Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD

Biomarker Insights
Hiroshi FurukawaShigeto Tohma

Abstract

Interstitial lung disease (ILD) is frequently associated with collagen disease. It is then designated as collagen vascular disease-associated ILD (CVD-ILD), and influences patients' prognosis. The prognosis of acute-onset diffuse ILD (AoDILD) occurring in patients with collagen disease is quite poor. Here, we report our investigation of auto-antibody (Ab) profiles to determine whether they may be useful in diagnosing CVD-ILD or AoDILD in collagen disease. Auto-Ab profiles were analyzed using the Lambda Array Beads Multi-Analyte System, granulocyte immunofluorescence test, Proto-Array Human Protein Microarray, AlphaScreen assay, and glutathione S-transferase capture enzyme-linked immunosorbent assay in 34 patients with rheumatoid arthritis (RA) with or without CVD-ILD and in 15 patients with collagen disease with AoDILD. The average anti-major histocompatibility complex class I-related chain A (MICA) Ab levels were higher in RA patients with CVD-ILD than in those without (P = 0.0013). The ratio of the average anti-MICA Ab level to the average anti-human leukocyte antigen class I Ab level (ie, MICA/Class I) was significantly higher in RA patients with CVD-ILD compared with those without (P = 4.47 × 10(-5)). To the best of our kno...Continue Reading

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Citations

Jul 1, 2020·Expert Review of Respiratory Medicine·Ritu KulshresthaRaj Kumar
Jul 3, 2021·Therapeutic Advances in Musculoskeletal Disease·Hiroshi FurukawaShigeto Tohma
Jan 14, 2020·Journal of Proteome Research·Feng FengThomas B Kepler

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Datasets Mentioned

BETA
GSE59687

Methods Mentioned

BETA
AlphaScreen
enzyme-linked immunosorbent assay
enzyme-linked
ELISA
ELISAs

Software Mentioned

AlphaScreen
HLA Fusion
ProtoArray
GIFT

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