Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity.

Neuromuscular Disorders : NMD
Nancy J OlsenDennis K Burns

Abstract

The objective of this case study was to characterize autoreactivity in two patients with non-autoimmune forms of muscle disease who had positivity for antinuclear antibodies (ANA) and Ro (SSA) autoantibodies. Serum samples from these two patients were applied to an autoantigen protein array with more than 70 specificities and were compared to samples from healthy controls and patients with systemic lupus erythematosus. Both myopathy patients had high levels of gliadin autoreactivity in serum and one patient had an overall autoantibody profile with lupus-like features. The findings suggest that some disorders of muscle that are considered non-autoimmune, may in fact have autoimmune features. Further examination of the role of subclinical gluten autoreactivity in the pathogenesis of myopathy syndromes has the potential to suggest improved approaches to diagnosis and treatment of these conditions.

References

Feb 9, 2002·Annals of Neurology·Duygu SelcenAndrew G Engel
Aug 13, 2003·Neurology·Anthony A Amato, Robert C Griggs
Sep 13, 2006·Muscle & Nerve·Albert Selva-O'CallaghanMiquel Vilardell-Tarrés
Oct 21, 2006·Journal of Autoimmunity·Amy E WandstratNancy J Olsen
Jan 24, 2007·Journal of Clinical Immunology·Branka Bonaci-NikolicMilos M Nikolic
Oct 4, 2008·The American Journal of Pathology·Akanchha KesariEric P Hoffman
Dec 17, 2008·British Medical Bulletin·John S LeedsDavid S Sanders

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Citations

Mar 4, 2011·Arthritis Research & Therapy·Quan-Zhen LiNancy J Olsen
Aug 3, 2021·Frontiers in Immunology·Andrea FariniYvan Torrente

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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