Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer.

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Liangdan TangShu-Wing Ng

Abstract

Mucinous epithelial ovarian cancers are clinically and morphologically distinct from the other histopathologic subtypes of ovarian cancer. Unlike other ovarian subtypes, epidemiologic studies have indicated that tobacco exposure is a significant risk factor for developing mucinous ovarian cancer. Detection of autoantibody reactivity is useful in biomarker discovery and for explaining the role of important pathophysiologic pathways in disease. In order to study if there are specific antibody biomarkers in the plasma samples of mucinous ovarian cancer patients, we have initiated a screen by employing a 'reverse capture antibody microarray' platform that uses native host antigens derived from mucinous ovarian tissues as 'baits' for the capture of differentially labelled patient and control autoantibodies. Thirty-five autoantibodies that were significantly elevated in the cancer plasma samples compared with healthy controls, and six autoantibodies that segregated smoking and non-smoking patients were identified. Functional annotation of the antibody targets has identified nine target antigens involved in integrin and Wnt signalling pathways. Immunohistochemistry of archived ovarian specimens showed significant overexpression of eig...Continue Reading

References

Apr 1, 1990·American Journal of Obstetrics and Gynecology·A BerchuckR C Bast
Jul 1, 1995·Nature Medicine·R LubinT Soussi
May 1, 1995·The Journal of Experimental Medicine·E LargerC Boitard
Oct 19, 1994·Journal of the National Cancer Institute·I WertheimS C Mok
Oct 1, 1996·Japanese Journal of Clinical Oncology·Y IchikawaK Uchida
Mar 31, 1998·Cancer Immunology, Immunotherapy : CII·S R ChinniD D Taylor
Feb 16, 2000·Obstetrics and Gynecology·P A MarchbanksH B Peterson
Aug 2, 2000·American Journal of Obstetrics and Gynecology·I KorneevaS S Witkin
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·A Novak, S Dedhar
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Apr 13, 2002·Annals of the New York Academy of Sciences·Grant R YeamanGillian A Lang
Jul 3, 2002·Epidemiology·Francesmary ModugnoCarrie M Cottreau
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sacha GnjaticLloyd J Old
Jan 14, 2004·American Journal of Epidemiology·Yuqing ZhangLynn Rosenberg
May 25, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Wanja KildalHåvard E Danielsen
Jan 21, 2006·Cancer Research·Madhumita ChatterjeeMichael A Tainsky
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fred W WamunyokoliMichael J Birrer
Mar 23, 2007·Molecular & Cellular Proteomics : MCP·Michel CaronRaymonde Joubert-Caron
Jul 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M L HarrisonM E Gore
Sep 11, 2007·Journal of Proteome Research·Barbara TomainoFrancesco Novelli
Oct 6, 2007·Molecular & Cellular Proteomics : MCP·Juan Madoz-GúrpideSam M Hanash
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael E HudsonMichael Snyder
Dec 20, 2007·Rheumatology International·Jin-Wuk HurSang-Cheol Bae
Sep 6, 2008·Science·D Williams ParsonsKenneth W Kinzler
Dec 17, 2009·Annals of the Rheumatic Diseases·V RiccieriG Valesini

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Citations

Aug 19, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Judith L LuborskyIngegerd Hellstrom
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Brian C-S LiuDennis J O'Rourke
Mar 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianguo ZhangYe Tian
Feb 16, 2013·Biochemical and Biophysical Research Communications·Ji Sun Lee, Soon Ji Yoo
Mar 13, 2016·Breast Cancer Research and Treatment·Maria Cristina RangelDavid S Salomon
Jun 10, 2011·Journal of Cellular and Molecular Medicine·C DesmetzJ Solassol
May 29, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun-Jun QiuKe-Qin Hua
Jul 4, 2013·Gynecologic Oncology·Suiyang ZhouRoss S Berkowitz
Mar 31, 2015·Indian Journal of Cancer·X DongP Lei
Jan 15, 2015·Medical Oncology·Ruobing LengLiangdan Tang
May 5, 2017·Expert Review of Molecular Diagnostics·Wei-Lei YangRobert C Bast
Nov 5, 2014·Journal of Proteome Research·Karen S AndersonJoshua LaBaer
Apr 2, 2013·Journal of Proteome Research·Jung-hyun Rho, Paul D Lampe

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