PMID: 6966403Mar 1, 1980Paper

Autoantibody to centromere (kinetochore) in scleroderma sera

Proceedings of the National Academy of Sciences of the United States of America
Y MoroiE M Tan

Abstract

Sera from patients with scleroderma contained several autoantibodies to nuclear antigens which were distinguished by different patterns of nuclear immunofluorescence staining. One of these autoantibodies reacted with centromeric regions of chromosomes. In chromosome spreads, the staining appeared as two small spheres at the centromere, resembling kinetochores. The antigenic determinant appeared to be a protein or polypeptide tightly bound to DNA. The autoantibody was reactive with centromeres of cells derived from humans, mice, and Chinese hamsters. The autoantibody was present in high frequency in the calcinosis/Raynaud's phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (CREST) of scleroderma.

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Citations

Aug 1, 1996·Arthritis and Rheumatism·J B RattnerM J Fritzler
Feb 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J B Rattner
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Jan 1, 1995·Journal of Biomedical Science·M. GabrieleF. Majone

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