Autoantibody with Cross-Reactivity between Insulin and Ductal Cells May Cause Diabetic Mastopathy: A Case Study.

Case Reports in Medicine
Katsutoshi MiuraHiroyuki Ogura

Abstract

Lymphocytic mastopathy or diabetic mastopathy is a benign breast disease characterized by dense fibrosis, lobular atrophy, and aggregates of lymphocytes in a periductal and perilobular distribution. The condition usually affects women with a long history of diabetes mellitus (DM) and also those with autoimmune disorders. While the pathogenesis is unknown, a particular type of class II human leukocyte antigen has been associated with this disease. Herein, we report a case of diabetic mastopathy which clinically and radiologically mimicked primary breast neoplasms. The patient was a 74-year-old woman with a 31-year history of DM type II who presented with multiple firm lumps in bilateral breasts. Findings from mammography, ultrasonography, and magnetic resonance imaging of the breasts revealed an abnormal appearance which suspiciously resembled malignancy. An aspiration cytology specimen showed atypical accumulation of lymphoid cells, leading us to suspect lymphoma. Histology of an excisional biopsy showed the characteristic appearance of lymphocytic mastopathy, which predominantly consisted of B-lymphocytes. Autoantibodies in her serum reacted positively against her ductal epithelium as well as other diabetic and nondiabetic bre...Continue Reading

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Citations

Aug 13, 2013·Case Reports in Surgery·R X KirbyS O Cawich
Nov 30, 2012·Annals of Diagnostic Pathology·Marilin Rosa, Amir Mohammadi
Mar 9, 2017·Annals of Plastic Surgery·Nneamaka Barbara Agochukwu, Lesley Wong
Apr 3, 2020·Journal of Clinical Medicine·Radjiv GoulabchandPhilippe Guilpain

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